The goal of the study is to better understand the neural mechanisms underlying the rewarding, reinforcing properties of delta-9-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, among healthy young adults.

Inclusion Criteria:

• must be able to give informed consent
• age 18-25 at the time of signing the consent form
• fluency in English
• body mass index of 19-26 (normal/overweight but not obese due to limitations of MRI)
• negative urine drug screen (UDS) for all substances except THC (THC allowed)
• must be medically and neurologically healthy
• must not be taking psychoactive medications that would interfere with dronabinol and/or interpretation of fMRI data, including but not limited to the following classes of psychotropics: antidepressants, anxiolytics, sedative hypnotics, stimulants, antipsychotics, mood stabilizer
• have used cannabis at least 10 times in their life, but report current and past lifetime cannabis use less than 7 days/week (daily)

Exclusion Criteria:

• any current medical condition requiring psychoactive/psychotropic medication or medication that would interact with dronabinol, interpretation of fMRI data, and/or interfere with study procedures
• current or past allergic or adverse reaction or known sensitivity to cannabinoid-like substances (Dronabinol/Marijuana/Cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide.)
• current Axis-I Diagnostic Statistical Manual-5 diagnosis (although mild and moderate Cannabis Use Disorder (CUD) and mild and moderate Alcohol Use Disorder (AUD) are allowed)
• score >3 on the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) for individuals with current AUD
• lifetime other lifetime Substance Use Disorder (although lifetime severe CUD and lifetime severe AUD are allowed)
• currently seeking or engaged in CUD treatment or have desire to cut down or stop cannabis use.
• in recovery or enrolled in treatment for any substance (including cannabis and alcohol)
• lifetime psychosis, mania, Attention-Deficit/Hyperactivity Disorder, Obsessive-Compulsive disorder, Feeding and Eating disorder, or Post-Traumatic Stress Disorder
• score >7 on the Hamilton Depression Rating Scale or score >7 on the Hamilton Anxiety Rating Scale
• less than a high school education
• lack of fluency in English
• night shift work
• currently pregnant confirmed by urine pregnancy test or planning pregnancy or lactating (women)
• unwilling/unable to sign informed consent document
• inability to tolerate small, enclosed spaces without anxiety (e.g. claustrophobia), as determined by self-report
• left-handed
• presence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles)
• positive UDS for any drug except THC
• positive breathalyzer for acute alcohol intoxication
• heavy alcohol use (>4 days week) in the past month
• heavy nicotine use (>20 cigarettes per week) in the past month

THC or placebo will be prescribed to participants by a licensed psychiatrist, and dispensed by the University of Illinois at Chicago's Investigational Drug Service (IDS). Staff at the Clinical Research Center will give the drug or placebo to participants with the PI or a physician designate, present on-site and/or available by pager.