Effects of Dronabinol (Oral THC) on Cannabis Use

Effects of Dronabinol (Oral THC) on Cannabis Use

Study participants received dronabinol (0, 120mg/day and 240mg/day) for 12 consecutive days in a randomized order. During each dronabinol maintenance period they were able to self-administer active or placebo cannabis using either a progressive ratio schedule or choice between cannabis and monetary alternative.

Inclusion Criteria:

• Current use of marijuana
• Able to give informed consent

Exclusion Criteria:

• Daily use of psychoactive medication
• Current Axis I psychiatric disorder other than dependence on cannabis or nicotine, or abuse of drugs or alcohol
• Women who are pregnant, breast feeding, or planning to become pregnant within the next 3 months
• Those seeking treatment for cannabis-related problems or using cannabis under the guidance of a physician for a medical disorder
• Uncontrolled or unstable cardiovascular disease
• Allergy to sesame oil