A Phase 3, Multicenter, Open-label, Randomized Study to Compare the Efficacy and Safety of MK-2870 Versus Treatment of Physician's Choice in 3L+ Advanced/Metastatic Gastroesophageal Adenocarcinoma (Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, and Esophageal Adenocarcinoma)
A Phase 3, Multicenter, Open-label, Randomized Study to Compare the Efficacy and Safety of MK-2870 Versus Treatment of Physician's Choice in 3L+ Advanced/Metastatic Gastroesophageal Adenocarcinoma (Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, and Esophageal Adenocarcinoma)
This study will compare how safe and effective sacituzumab tirumotecan is versus the treatment of physician's choice (TPC) in participants with advanced/metastatic gastroesophageal adenocarcinoma. The primary hypothesis of this study is sacituzumab tirumotecan is superior to TPC with respect to Overall Survival (OS).
Inclusion Criteria:
Exclusion Criteria:
Orlando, Florida 32804, United States
Marietta, Georgia 30060, United States
Lexington, Kentucky 40536, United States
Louisville, Kentucky 40202, United States
Louisville, Kentucky 40217, United States
Fargo, North Dakota 58122, United States
Charleston, South Carolina 29425, United States
Anderlecht, Bruxelles-Capitale, Region de 1070, Belgium
Brussels, Bruxelles-Capitale, Region de 1200, Belgium
Fortaleza, Ceará 60430235, Brazil
Natal, Rio Grande do Norte 59075-740, Brazil
Porto Alegre, Rio Grande do Sul 91350-200, Brazil
Barretos, São Paulo 14784-400, Brazil
São José do Rio Preto, São Paulo 15090000, Brazil
Santiago, Region M. de Santiago 7620002, Chile
Hefei, Anhui 230000, China
Chongqing, Chongqing Municipality 404000, China
Fuzhou, Fujian 350025, China
Xiamen, Fujian 361003, China
Guangzhou, Guangdong 510515, China
Harbin, Heilongjiang 150081, China
Nanchang, Jiangxi 330006, China
Shanghai, Shanghai Municipality 200032, China
Shanghai, Shanghai Municipality 200032, China
Shanghai, Shanghai Municipality 200127, China
Nanchong, Sichuan 637199, China
Ürümqi, Xinjiang 830011, China
Hangzhou, Zhejiang 310016, China
Bogotá, Bogota D.C. 110131, Colombia
Bogotá, Bogota D.C. 111321, Colombia
Valledupar, Cesar Department 200001, Colombia
Cali, Valle del Cauca Department 760032, Colombia
Aalborg, North Denmark 9000, Denmark
Odense, Region Syddanmark 5000, Denmark
Bordeaux, Aquitaine 33076, France
Rennes, Ille-et-Vilaine 35042, France
Göttingen, Lower Saxony 37075, Germany
Dresden, Saxony 01307, Germany
Kiel, Schleswig-Holstein 24116, Germany
Berlin, 13353, Germany
Naples, Campania 80131, Italy
Rome, Lazio 00168, Italy
Milan, Lombardy 20133, Italy
Kitaadachi-gun, Saitama 362-0806, Japan
Koto, Tokyo 135-8550, Japan
Osaka, 541-8567, Japan
Putrajaya, Putrajaya 62250, Malaysia
Mexico City, Mexico City 04700, Mexico
Mexico City, Mexico City 14080, Mexico
Monterrey, Nuevo León 64460, Mexico
San Luis Potosí City, San Luis Potosí 78250, Mexico
Concepción, Departamento de Junín 12125, Peru
Trujillo, La Libertad 13002, Peru
Lima, 15036, Peru
Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85-796, Poland
Warsaw, Masovian Voivodeship 02-034, Poland
Gdynia, Pomeranian Voivodeship 81-519, Poland
Poland, West Pomeranian Voivodeship 75-581, Poland
Kielce, Świętokrzyskie Voivodeship 25-734, Poland
Seoul, 03722, South Korea
Oviedo, Principality of Asturias 33011, Spain
Barcelona, 08035, Spain
Adana, 01250, Turkey (Türkiye)
Istanbul, 34722, Turkey (Türkiye)
Van, 65200, Turkey (Türkiye)
Dundee, Dundee City DD2 1SG, United Kingdom