A Randomized, Open-label, Phase 3 Study of MK-2870 vs. Platinum Doublets in Participants With EGFR-mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors
A Randomized, Open-label, Phase 3 Study of MK-2870 vs. Platinum Doublets in Participants With EGFR-mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors
The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs).
The primary hypotheses of this study is that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pemetrexed and carboplatin) in regard to overall survival (OS).
Participants will be randomized 1:1 into two arms:
Participants will receive treatment until any of the criteria for discontinuation of study intervention are met.
Inclusion Criteria:
Exclusion Criteria:
Marietta, Georgia 30060, United States
Springfield, Missouri 65807, United States
Caba., Buenos Aires C1430EGF, Argentina
Ciudad Autónoma de Buenos Aires, Buenos Aires C1426ANZ, Argentina
Buenos Aires, Buenos Aires F.D. C1280AEB, Argentina
Río Cuarto, Córdoba Province X5800ALB, Argentina
La Rioja, F5300COE, Argentina
Beijing, Beijing Municipality 100730, China
Chongqing, Chongqing Municipality 400030, China
Guangzhou, Guangdong 510515, China
Nanning, Guangxi 530021, China
Changsha, Hunan 410011, China
Nanjing, Jiangsu 210031, China
Suzhou, Jiangsu 215006, China
Xi'an, Shaanxi 710004, China
Hangzhou, Zhejiang 310006, China
Hangzhou, Zhejiang 310016, China
Wenzhou, Zhejiang 325015, China
Bogotá, Bogota D.C. 110131, Colombia
Bogotá, Bogota D.C. 111321, Colombia
Valledupar, Cesar Department 200002, Colombia
Cali, Valle del Cauca Department 760032, Colombia
Paris, 75014, France
Mumbai, Maharashtra 400053, India
New Delhi, National Capital Territory of Delhi 110029, India
New Delhi, National Capital Territory of Delhi 110076, India
New Delhi, National Capital Territory of Delhi 110085, India
Bari, Apulia 70124, Italy
Milan, Lombardy 20133, Italy
Milan, Lombardy 20141, Italy
Florence, Tuscany 50134, Italy
Roma, 00168, Italy
Kitaadachi-gun, Saitama 362-0806, Japan
Sunto-gun, Shizuoka 411-8777, Japan
Osaka, 541-8567, Japan
Lembah Pantai, Kuala Lumpur 59100, Malaysia
Putrajaya, Kuala Lumpur 62250, Malaysia
George Town, Pulau Pinang 10450, Malaysia
Monterrey, Nuevo León 64460, Mexico
Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85-796, Poland
Warsaw, Masovian Voivodeship 02-781, Poland
Gliwice, Silesian Voivodeship 44-102, Poland
Suwon, Kyonggi-do 16247, South Korea
Daegu, Taegu-Kwangyokshi 42601, South Korea
Seoul, 03312, South Korea
LHospitalet de Llobregat, Barcelona 08908, Spain
Santiago de Compostela, La Coruna 15706, Spain
Seville, 41009, Spain
Taipei City, Taipei 106, Taiwan
Taoyuan, 333, Taiwan
Bangkoknoi, Bangkok 10700, Thailand
Dusit, Bangkok 10300, Thailand
Muang, Changwat Khon Kaen 40002, Thailand
Ratchathewi, Changwat Ratchaburi 10400, Thailand
Muang, Chiang Mai 50200, Thailand
Tan Binh District, Ho Chi Minh 700000, Vietnam