A Phase 3, Randomized, Active-controlled, Open-label, Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician's Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Immunotherapy (MK-2870-005/ENGOT-en23/GOG-3095)
A Phase 3, Randomized, Active-controlled, Open-label, Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician's Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Immunotherapy (MK-2870-005/ENGOT-en23/GOG-3095)
Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with platinum based therapy (a type of chemotherapy) and immunotherapy. Immunotherapy is a treatment that helps the immune system fight cancer. This clinical study will compare sacituzumab tirumotecan to chemotherapy. The goal of the study is to learn if people who receive sacituzumab tirumotecan live longer overall and without the cancer getting worse compared to people who receive chemotherapy.
The main inclusion and exclusion criteria include but are not limited to the following:
Inclusion Criteria:
Exclusion Criteria:
Los Angeles, California 90095, United States
San Francisco, California 94109, United States
New Haven, Connecticut 06511, United States
Washington D.C., District of Columbia 20010, United States
Orlando, Florida 32804, United States
Evanston, Illinois 60201, United States
Fort Wayne, Indiana 46845, United States
Edgewood, Kentucky 41017, United States
Worcester, Massachusetts 01605, United States
St Louis, Missouri 63110, United States
Hackensack, New Jersey 07601, United States
Morristown, New Jersey 07960, United States
Brooklyn, New York 11215, United States
Mineola, New York 11501, United States
New York, New York 10029, United States
Philadelphia, Pennsylvania 19107, United States
Pittsburgh, Pennsylvania 15244, United States
Sioux Falls, South Dakota 57104, United States
Houston, Texas 77030, United States
Ciudad Autónoma de Buenos Aires, Buenos Aires C1280AEB, Argentina
Buenos Aires, Buenos Aires F.D. C1122AAL, Argentina
Buenos Aires, Buenos Aires F.D. C1426ANZ, Argentina
Buenos Aires, C1431FWO, Argentina
La Rioja, F5300COE, Argentina
Innsbruck, Tyrol 6020, Austria
Joinville, Santa Catarina 89201260, Brazil
Hefei, Anhui 230000, China
Xiamen, Fujian 361003, China
Guangzhou, Guangdong 510000, China
Nanning, Guangxi 530021, China
Harbin, Heilongjiang 150000, China
Wuhan, Hubei 430022, China
Nanchang, Jiangxi 330000, China
Shanghai, Shanghai Municipality 200011, China
Shanghai, Shanghai Municipality 201204, China
Chengdu, Sichuan 610000, China
Hangzhou, Zhejiang 310006, China
Wenzhou, Zhejiang 325015, China
Brno, Brno-mesto 602 00, Czechia
Ostrava, Moravian-Silesian Region 708 52, Czechia
Nový Jiín, Novy Jicin 741 01, Czechia
Prague, Praha 2 12808, Czechia
Prague, Praha 8 180 00, Czechia
Copenhagen, Capital Region 2730, Denmark
Turku, Southwest Finland 20520, Finland
Helsinki, Uusimaa 00029, Finland
Bordeaux, Aquitaine 33076, France
Lyon Cedex08, Auvergne-Rhône-Alpes 69373, France
Plérin, Cotes-d Armor 22190, France
Rennes, Ille-et-Vilaine 35042, France
Mannheim, Baden-Wurttemberg 68167, Germany
Ravensburg, Baden-Wurttemberg 88212, Germany
Munich, Bavaria 81337, Germany
Essen, North Rhine-Westphalia 45136, Germany
Dresden, Saxony 01307, Germany
Bologna, Emilia-Romagna 40138, Italy
Milan, Lombardy 20133, Italy
Rozzano, Milano 20089, Italy
Candiolo, Torino 10060, Italy
Brescia, 25123, Italy
Naples, 80131, Italy
Roma, 00168, Italy
Otashi, Gunma 373-8550, Japan
Shiwa-gun, Iwate 028-3695, Japan
Sunto-gun,, Shizuoka 411-8777, Japan
Chuo-ku, Tokyo 104-0045, Japan
Koto, Tokyo 135-8550, Japan
Shinagawa, Tokyo 142-8666, Japan
Osaka, 541-8567, Japan
Coyoacán, Mexico City 04700, Mexico
San Pedro Garza García, Nuevo León 66278, Mexico
Leiden, South Holland 2333 ZA, Netherlands
Poznan, Greater Poland Voivodeship 61-866, Poland
Siedlce, Masovian Voivodeship 08-110, Poland
Warsaw, Masovian Voivodeship 02-781, Poland
Bialystok, Podlaskie Voivodeship 15-027, Poland
San Juan, 00935, Puerto Rico
Singapore, Central Singapore 168583, Singapore
Seongnam, Kyonggi-do 13620, South Korea
Seoul, 03722, South Korea
Seoul, 05505, South Korea
L'Hospitalet de Llobregat, Barcelona 08908, Spain
Madrid, Madrid, Comunidad de 28041, Spain
Madrid, Madrid, Comunidad de 28046, Spain
Valencia, Valenciana, Comunitat 46009, Spain
Barcelona, 08035, Spain
Basel, Canton of Basel-City 4031, Switzerland
East Sussex, Brighton And Hove BN2 1ES, United Kingdom
London, England SW3 6JJ, United Kingdom
London, London, City of NW1 2PG, United Kingdom
London, London, City of SE1 9RT, United Kingdom