A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants... | NCT06459180 | Trialant

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants... | NCT06459180 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Has histologically-confirmed diagnosis of squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix

Must have recurrent or metastatic cervical cancer that has progressed on or after treatment with 1 prior line of systemic platinum doublet chemotherapy (with or without bevacizumab) AND must have received anti-PD-1/anti-PD-L1 therapy as part of prior cervical cancer regimens

Has measurable disease per Response Evaluation Criteria In Solid Tumors (RECIST) 1.1, as assessed by the investigator. Lesions situated in a previously irradiated area are considered measurable if progression has been shown in such lesions

Is assigned female sex at birth, at least 18 years of age at the time of providing the informed consent

Has ECOG performance status of 0 or 1 within 7 days before allocation for the Sacituzumab Tirumotecan Run-in or within 7 days before randomization for the Phase 3 portion

Has provided tumor tissue (most recent sample is preferred) from a core or excisional biopsy of a tumor lesion not previously irradiated

HIV-infected participants must have well controlled human immunodeficiency virus (HIV) on antiretroviral therapy (ART)

Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load prior to allocation (Sacituzumab Tirumotecan Run-in) or randomization (Phase 3 portion)

Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening

Has adequate organ function

Exclusion Criteria:

Has Grade ≥2 peripheral neuropathy

Has history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing

Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, or chronic diarrhea)

Has uncontrolled, significant cardiovascular disease or cerebrovascular disease.

Received prior systemic anticancer therapy

Received prior radiotherapy within 2 weeks of start of study intervention, or has radiation-related toxicities, requiring corticosteroids

Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed

Has other histological subtypes of cervical cancer apart from squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma (eg, carcinosarcoma), or has a diagnosis of nonepithelial cancer (eg, sarcoma, neuroendocrine tumors) of the cervix.

Known additional malignancy that is progressing or has required active treatment within the past 3 years

Known active central nervous system (CNS) metastases and/or carcinomatous meningitis

Active infection requiring systemic therapy

HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease

Concurrent active Hepatitis B and active Hepatitis C virus infection

Severe hypersensitivity (≥Grade 3) to sacituzumab tirumotecan or treatment of physician's choice (TPC) and/or any of their excipients, or other biologic therapy

Participants who have not adequately recovered from major surgery or have ongoing surgical complications

Has a history of (noninfectious) pneumonitis/ILD that required steroids or has current pneumonitis/ILD

USA Mitchell Cancer Institute-Clinical Trials ( Site 4126)

Mobile, Alabama 36604, United States

Providence Alaska Medical Center ( Site 4137)

Anchorage, Alaska 99508, United States

HonorHealth (HH) ( Site 8002)

Phoenix, Arizona 85016, United States

Arizona Oncology Associates - HOPE ( Site 8001)

Tucson, Arizona 85711, United States

Moores Cancer Center-Clinical Trials Office - Gynecological Oncology ( Site 4125)

La Jolla, California 92093, United States

UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4105)

Los Angeles, California 90095, United States

Hoag Memorial Hospital Presbyterian ( Site 4104)

Newport Beach, California 92663, United States

Mount Sinai Braman Comprehensive Cancer Center ( Site 4143)

Miami Beach, Florida 33140, United States

Advent Health ( Site 4140)

Orlando, Florida 32804, United States

Florida Cancer Specialists East ( Site 7001)

West Palm Beach, Florida 33401, United States

Northside Hospital ( Site 4127)

Atlanta, Georgia 30342, United States

Georgia Cancer Center at Augusta University ( Site 4112)

Augusta, Georgia 30912, United States

Lewis Cancer and Research Pavilion ( Site 4114)

Savannah, Georgia 31405, United States

University Medical Center New Orleans ( Site 4132)

New Orleans, Louisiana 70112, United States

Willis Knighton Medical Center ( Site 4101)

Shreveport, Louisiana 71103, United States

The Center of Hope ( Site 4106)

Reno, Nevada 89511, United States

Holy Name Medical Center ( Site 4117)

Teaneck, New Jersey 07666, United States

Optimum Clinical Research Group ( Site 4138)

Albuquerque, New Mexico 87109, United States

Perlmutter Cancer Center NYU Langone Hospital - Long Island ( Site 4145)

Mineola, New York 11501, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 4121)

New York, New York 10016, United States

Duke Cancer Institute ( Site 4120)

Durham, North Carolina 27710, United States

University of Cincinnati Medical Center ( Site 4128)

Cincinnati, Ohio 45219, United States

The Ohio State University ( Site 4103)

Hilliard, Ohio 43026, United States

Oklahoma Cancer Specialists and Research Institute, LLC-Clinical Research ( Site 4116)

Tulsa, Oklahoma 74146, United States

Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007)

Eugene, Oregon 97401, United States

Legacy Good Samaritan Medical Center-Oncology Clinical Research ( Site 4115)

Portland, Oregon 97210, United States

Sidney Kimmel Cancer Center - Jefferson Health ( Site 4142)

Philadelphia, Pennsylvania 19107, United States

Asplundh Cancer Pavilion ( Site 4113)

Willow Grove, Pennsylvania 19090, United States

The West Clinic, PLLC dba West Cancer Center ( Site 4108)

Germantown, Tennessee 38138, United States

Texas Oncology - Central/South Texas ( Site 8010)

Austin, Texas 78731, United States

Texas Oncology - DFW ( Site 8003)

Fort Worth, Texas 76104, United States

Houston Methodist Hospital OB/GYN ( Site 4102)

Houston, Texas 77030, United States

Texas Oncology - San Antonio ( Site 8006)

San Antonio, Texas 78240, United States

Texas Oncology - Northeast Texas ( Site 8009)

Tyler, Texas 75702, United States

Texas Oncology - Gulf Coast ( Site 8008)

Webster, Texas 77598, United States

University of Virginia Cancer Center ( Site 4123)

Charlottesville, Virginia 22908, United States

Inova Schar Cancer Institute ( Site 4139)

Fairfax, Virginia 22031-4867, United States

Swedish Medical Center-Swedish Cancer Institute ( Site 4134)

Seattle, Washington 98104, United States

Hospital Británico de Buenos Aires-Oncology ( Site 0102)

Ciudad Autónoma de Buenos Aires, Buenos Aires C1280AEB, Argentina

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0107)

Mar del Plata, Buenos Aires B7600FZO, Argentina

Instituto de Oncología Angel H. Roffo ( Site 0103)

Buenos Aires, Buenos Aires F.D. C1417, Argentina

Instituto Alexander Fleming ( Site 0108)

Buenos Aires, Buenos Aires F.D. C1426ANZ, Argentina

Sanatorio Allende - Cerro-Oncology ( Site 0106)

Córdoba, Córdoba Province 5000, Argentina

Hospital Aleman-Oncology ( Site 0100)

Buenos Aires, C1118AAT, Argentina

Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0109)

CABA, C1431FWO, Argentina

Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0104)

La Rioja, F5300COE, Argentina

Blacktown Hospital ( Site 3006)

Sydney, New South Wales 2148, Australia

Campbelltown Hospital-Macarthur Cancer Therapy Centre Medical Oncology ( Site 3000)

Sydney, New South Wales 2560, Australia

Royal Brisbane and Women's Hospital ( Site 3001)

Herston, Queensland 4029, Australia

Monash Health-Oncology Research ( Site 3002)

Clayton, Victoria 3168, Australia

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3005)

Melbourne, Victoria 3000, Australia

Sir Charles Gairdner Hospital ( Site 3003)

Nedlands, Western Australia 6009, Australia

Medizinische Universität Graz-Abteilung für Gynäkologie / Onkologie ( Site 1003)

Graz, Styria 8036, Austria

Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 1000)

Innsbruck, Tyrol 6020, Austria

Kepler Universitätsklinikum-Department for Oncology and Hematology ( Site 1002)

Linz, Upper Austria 4020, Austria

Medizinische Universität Wien ( Site 1001)

Vienna, 1090, Austria

AZORG Campus Aalst-Moorselbaan ( Site 2905)

Aalst, Oost-Vlaanderen 9300, Belgium

UZ Gent-Medical oncology ( Site 2901)

Ghent, Oost-Vlaanderen 9000, Belgium

UZ Leuven-Gynecologic Oncology ( Site 2900)

Leuven, Vlaams-Brabant 3000, Belgium

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman-Medical Oncology ( Site 2904)

Belgium, Wallonne, Region 4000, Belgium

CHU UCL Namur/Site Sainte Elisabeth-Trial Office ( Site 2902)

Namur, 5000, Belgium

Instituto do Câncer e Transplante de Curitiba ( Site 0205)

Curitiba, Paraná 80510130, Brazil

Hospital Moinhos de Vento-Centro de Pesquisa Clínica ( Site 0204)

Porto Alegre, Rio Grande do Sul 90035-001, Brazil

Hospital do Câncer Mãe de Deus ( Site 0201)

Porto Alegre, Rio Grande do Sul 90110-270, Brazil

Centro de Hematologia e Oncologia ( Site 0203)

Joinville, Santa Catarina 89202-050, Brazil

IBCC - Instituto Brasileiro de Controle do Câncer-Centro de Pesquisa Clínica ( Site 0200)

São Paulo, São Paulo 04014-002, Brazil

Americas Centro de Oncologia Integrado ( Site 0202)

Rio de Janeiro, 22775-001, Brazil

Hospital Paulistano ( Site 0209)

São Paulo, 01321-001, Brazil

MBAL Uni Hospital-Department of Medical Oncology ( Site 1104)

Panagyurishte, Pazardzhik 4500, Bulgaria

MHAT - Heart and Brain ( Site 1100)

Pleven, 5804, Bulgaria

Complex Oncology Center - Plovdiv EOOD ( Site 1102)

Plovdiv, 4004, Bulgaria

BC Cancer Kelowna ( Site 4007)

Kelowna, British Columbia V1Y 5L3, Canada

BC Cancer Surrey ( Site 4006)

Surrey, British Columbia V3V 1Z2, Canada

BC Cancer Victoria ( Site 4008)

Victoria, British Columbia V8R 6V5, Canada

Royal Victoria Regional Health Centre ( Site 4009)

Barrie, Ontario L4M 6M2, Canada

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 4003)

Hamilton, Ontario L8V 5C2, Canada

Centre Hospitalier de l'Université de Montréal ( Site 4001)

Montreal, Quebec H2X 0C1, Canada

McGill University Health Centre ( Site 4000)

Montreal, Quebec H4A 3J1, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 4002)

Québec, Quebec G1J 1Z4, Canada

FALP-UIDO ( Site 0300)

Santiago, Region M. de Santiago 7500921, Chile

Pontificia Universidad Catolica de Chile ( Site 0302)

Santiago, Region M. de Santiago 832000, Chile

ONCOCENTRO APYS-ACEREY ( Site 0303)

Viña del Mar, Valparaiso 2520598, Chile

Anhui Provincial Cancer Hospital-Gynecological Oncology ( Site 5040)

Hefei, Anhui 230000, China

Anhui Provincial Hospital ( Site 5011)

Hefei, Anhui 230071, China

Beijing Peking Union Medical College Hospital ( Site 5045)

Beijing, Beijing Municipality 100730, China

Chongqing University Cancer Hospital ( Site 5003)

Chongqing, Chongqing Municipality 400030, China

Fujian Provincial Cancer Hospial ( Site 5012)

Fuzhou, Fujian 350014, China

The First Affiliated hospital of Xiamen University-Obstetrics and gynecology department ( Site 5027)

Xiamen, Fujian 361003, China

Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 5001)

Guangzhou, Guangdong 510000, China

Sun Yat-sen University Cancer Center-Internal medicine ( Site 5006)

Guangzhou, Guangdong 511400, China

Affiliated Hospital of Guangdong Medical University ( Site 5004)

Zhanjiang, Guangdong 524004, China

Guangxi Medical University Affiliated Tumor Hospital ( Site 5016)

Nanning, Guangxi 530200, China

Hainan General Hospital ( Site 5032)

Haikou, Hainan 570311, China

Harbin Medical University Cancer Hospital ( Site 5010)

Harbin, Heilongjiang 150081, China

The First Affiliated Hospital of Xinxiang Medical University-Oncology ( Site 5041)

Xinxiang, Henan 453100, China

Henan Cancer Hospital ( Site 5026)

Zhengzhou, Henan 450008, China

Wuhan Union Hospital ( Site 5020)

Wuhan, Hubei 430048, China

Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 5019)

Wuhan, Hubei 430079, China

Hunan Cancer Hospital ( Site 5021)

Changsha, Hunan 410013, China

Xiangya Hospital Central South University ( Site 5009)

Changsha, Hunan 410028, China

Jiangsu Province Hospital-Oncology Department ( Site 5018)

Nanjing, Jiangsu 210036, China

Jiangxi Maternal and Child Health Hospital ( Site 5031)

Nanchang, Jiangxi 330077, China

Jilin Province Tumor Hospital ( Site 5036)

Changchun, Jilin 130000, China

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 5007)

Xi'an, Shaanxi 710061, China

Shandong Cancer Hospital ( Site 5014)

Jinan, Shandong 250117, China

LinYi Cancer Hospital-Gastrology department ( Site 5039)

Linyi, Shandong 276000, China

Obstetrics & Gynecology Hospital of Fudan University ( Site 5015)

Shanghai, Shanghai Municipality 200011, China

Shanxi Cancer Hospital ( Site 5043)

Taiyuan, Shanxi 030000, China

West China Second University Hospital, Sichuan University ( Site 5017)

Chengdu, Sichuan 610000, China

Sichuan Cancer hospital-Oncology ( Site 5030)

Chengdu, Sichuan 610041, China

Yunnan Province Cancer Hospital-Gynecology Department ( Site 5005)

Kunming, Yunnan 650107, China

Women s Hospital School of Medicine Zhejiang University ( Site 5022)

Hangzhou, Zhejiang 310006, China

Zhejiang Cancer Hospital ( Site 5008)

Hangzhou, Zhejiang 310022, China

The First Affiliated Hospital of Wenzhou Medical University ( Site 5033)

Wenzhou, Zhejiang 325015, China

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0403)

Bogotá, Bogota D.C. 110131, Colombia

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0401)

Valledupar, Cesar Department 200001, Colombia

Instituto Nacional De Cancerologia-Oncología Clínica ( Site 0404)

Bogota, Cundinamarca 111151, Colombia

IMAT S.A.S ( Site 0402)

Montería, Departamento de Córdoba 230002, Colombia

Oncologos del Occidente ( Site 0405)

Pereira, Risaralda Department 660001, Colombia

Fundación Valle del Lili ( Site 0406)

Cali, Valle del Cauca Department 760032, Colombia

Rigshospitalet-Dept. of Oncology ( Site 1300)

Copenhagen, Capital Region 2100, Denmark

Aarhus Universitetshospital, Skejby ( Site 1301)

Aarhus, Central Jutland 8200, Denmark

Odense Universitetshospital-Department of oncology ( Site 1302)

Odense C, Region Syddanmark 5000, Denmark

Tampereen yliopistollinen sairaala-Gynecology and Obstetrics ( Site 1404)

Tampere, Pirkanmaa 33520, Finland

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1401)

Turku, Southwest Finland 20520, Finland

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1400)

Helsinki, Uusimaa 00029, Finland

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1503)

Bordeaux, Aquitaine 33076, France

CENTRE LEON BERARD ( Site 1505)

Lyon Cedex08, Auvergne-Rhône-Alpes 69373, France

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1508)

Clermont-Ferrand, Auvergne 63011, France

Hopitaux Universitaires de Strasbourg ( Site 1501)

Strasbourg, Bas-Rhin 67200, France

Institut Paoli-Calmettes ( Site 1504)

Marseille, Bouches-du-Rhone 13009, France

Hôpital Privé Des Côtes d'Armor ( Site 1510)

Plérin, Cotes-d Armor 22190, France

CHU Besançon ( Site 1507)

Besançon, Franche-Comte 25030, France

LBM ONCOPOLE CLAUDIUS REGAUD ( Site 1502)

Toulouse, Haute-Garonne 31059, France

Institut Regional du Cancer Montpellier ( Site 1511)

Montpellier, Herault 34298, France

Hôpital privé du Confluent SAS ( Site 1509)

Nantes, Loire-Atlantique 44277, France

Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1506)

Paris, 75020, France

Gustave Roussy ( Site 1512)

Villejuif, Île-de-France Region 94805, France

Universitaetsklinikum Heidelberg Nationales Centrum fuer Tumorerkrankungen ( Site 1612)

Heidelberg, Baden-Wurttemberg 69120, Germany

SLK-Kliniken Heilbronn ( Site 1617)

Heilbronn, Baden-Wurttemberg 74078, Germany

Diakonie-Klinikum Schwaebisch-Hall gGmbH Frauenklinik ( Site 1614)

Schwäbisch Hall, Baden-Wurttemberg 74523, Germany

Klinikum der Universität München Großhadern-Klinik und Poliklinik für Frauenheilkunde und Geburtshi ( Site 1605)

Munich, Bavaria 81377, Germany

Universitätsklinikum Marburg ( Site 1604)

Marburg, Hesse 35043, Germany

Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1607)

Düsseldorf, North Rhine-Westphalia 40225, Germany

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinik für Gynäkologie und Gynäkologische Onko ( Site 1600)

Essen, North Rhine-Westphalia 45136, Germany

Universitaetsklinikum Essen ( Site 1613)

Essen, North Rhine-Westphalia 45147, Germany

Klinikum Worms ( Site 1619)

Worms, Rhineland-Palatinate 67550, Germany

Universitaetsklinikum des Saarlandes ( Site 1618)

Homburg, Saarland 66421, Germany

Universitaetsklinikum Hamburg-Eppendorf-Department of Gynecology ( Site 1611)

Hamburg, 20246, Germany

Aretaieio Hospital ( Site 1700)

Athens, Attica 115 28, Greece

Mitera Hospital ( Site 1702)

Athens, Attica 151 23, Greece

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1703)

Chaïdári, Attica 124 62, Greece

Agios Andreas Hospital Patras ( Site 1701)

Patras, Peloponnese 263 35, Greece

Cork University Hospital ( Site 1900)

Cork, T12 E8YV, Ireland

Mater Misericordiae University Hospital ( Site 1901)

Dublin, D07 R2WY, Ireland

St. James's Hospital-Cancer clinical trials office ( Site 1902)

Dublin, D08 E9P6, Ireland

Rambam Health Care Campus ( Site 2002)

Haifa, 3109601, Israel

Edith Wolfson Medical Center ( Site 2003)

Holon, 5810001, Israel

Hadassah Medical Center ( Site 2000)

Jerusalem, 9112001, Israel

Sheba Medical Center ( Site 2001)

Ramat Gan, 5265601, Israel

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlin-DEPARTMENT OF EXPERIMENTAL, DIAGNOSTIC ( Site 2105)

Bologna, Emilia-Romagna 40138, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 2107)

Milan, Lombardy 20133, Italy

Ospedale Humanitas San Pio X ( Site 2113)

Milan, Lombardy 20159, Italy

Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2111)

Monza, Lombardy 20900, Italy

Humanitas University ( Site 2112)

Rozzano, Milano 20089, Italy

Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 2100)

Turin, Piedmont 10128, Italy

Azienda Ospedaliera Spedali Civili di Brescia-Obstetrics anf gynecology ( Site 2110)

Brescia, 25123, Italy

Ospedale Cannizzaro ( Site 2104)

Catania, 95126, Italy

Ospedale San Raffaele. ( Site 2106)

Milan, 20132, Italy

Istituto Europeo di Oncologia IRCCS ( Site 2108)

Milan, 20141, Italy

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2103)

Naples, 80131, Italy

Istituto Oncologico Veneto IRCCS ( Site 2109)

Padova, 35128, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2102)

Roma, 00168, Italy

Aichi Cancer Center ( Site 5110)

Nagoya, Aichi-ken 464-8681, Japan

National Cancer Center Hospital East ( Site 5113)

Kashiwa, Chiba 277-8577, Japan

National Hospital Organization Shikoku Cancer Center ( Site 5109)

Matsuyama, Ehime 791-0280, Japan

Ehime University Hospital ( Site 5102)

Tōon, Ehime 791-0295, Japan

Kurume University Hospital ( Site 5105)

Kurume, Fukuoka 830-0011, Japan

Gunma Prefectural Cancer Center ( Site 5116)

Ohta, Gunma 373-8550, Japan

Hokkaido University Hospital ( Site 5106)

Sapporo, Hokkaido 060-8648, Japan

University of Tsukuba Hospital ( Site 5114)

Tsukuba, Ibaraki 305-8576, Japan

Iwate Medical University Hospital ( Site 5112)

Shiwa-gun, Iwate 028-3695, Japan

Saitama Medical University International Medical Center ( Site 5117)

Hidaka, Saitama 350-1298, Japan

Shizuoka Cancer Center ( Site 5107)

Sunto-gun,, Shizuoka 411-8777, Japan

National Cancer Center Hospital ( Site 5108)

Chūō, Tokyo 104-0045, Japan

Cancer Institute Hospital of JFCR ( Site 5111)

Koto, Tokyo 135-8550, Japan

The Jikei University Hospital ( Site 5118)

Minato, Tokyo 105-8471, Japan

Keio University Hospital ( Site 5101)

Shinjyuku, Tokyo 160-8582, Japan

National Hospital Organization Kyushu Cancer Center ( Site 5104)

Fukuoka, 811-1395, Japan

Kagoshima City Hospital ( Site 5115)

Kagoshima, 890-8760, Japan

Niigata Cancer Center Hospital ( Site 5100)

Niigata, 951-8566, Japan

Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 5103)

Osaka, 541-8567, Japan

University Malaya Medical Centre ( Site 3102)

Lembah Pantai, Kuala Lumpur 59100, Malaysia

Sunway Medical Centre ( Site 3105)

Petaling Jaya, Selangor 47500, Malaysia

Pantai Hospital Kuala Lumpur ( Site 3100)

Kuala Lumpur, 59100, Malaysia

Penang Adventist Hospital ( Site 3101)

Pulau Pinang, 10350, Malaysia

CENEIT Oncologicos ( Site 0507)

Mexico City, Mexico City 03100, Mexico

Oncare - Unidad Valle ( Site 0509)

San Pedro Garza García, Nuevo León 66220, Mexico

Centro de Investigacion Clinica de Oaxaca ( Site 0505)

Oaxaca City, Oaxaca 68020, Mexico

Centro de Investigación Oncológica Galerías SC ( Site 0508)

Aguascalientes, 20124, Mexico

Centro de Atención e Investigación Cardiovascular del Potosí ( Site 0506)

San Luis Potosí City, 78200, Mexico

Radboudumc-Medical Oncology ( Site 2202)

Nijmegen, Gelderland 6525 GA, Netherlands

Catharina Ziekenhuis-Oncology ( Site 2203)

Eindhoven, North Brabant 5623 EJ, Netherlands

Amsterdam UMC, locatie VUmc ( Site 2201)

Amsterdam, North Holland 1081 HV, Netherlands

Erasmus Medisch Centrum-Medical Oncology ( Site 2200)

Rotterdam, South Holland 3015 GD, Netherlands

University Medical Center Groningen ( Site 2204)

Groningen, 9713 GZ, Netherlands

Oslo universitetssykehus, Radiumhospitalet ( Site 2300)

Oslo, 0379, Norway

Uniwersytecki Szpital Kliniczny w Poznaniu-Klinika Ginekologii Onkologicznej ( Site 2404)

Poznan, Greater Poland Voivodeship 60-569, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 2400)

Warsaw, Masovian Voivodeship 02-781, Poland

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2402)

Bialystok, Podlaskie Voivodeship 15-027, Poland

UPR Comprehensive Cancer Center-Comprehensive Cancer Center Hospital ( Site 0601)

San Juan, 00935, Puerto Rico

National University Hospital ( Site 3301)

Singapore, Central Singapore 119228, Singapore

National Cancer Centre Singapore ( Site 3300)

Singapore, Central Singapore 168583, Singapore

Seoul National University Hospital ( Site 3403)

Seoul, 03080, South Korea

Severance Hospital, Yonsei University Health System ( Site 3402)

Seoul, 03722, South Korea

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 3401)

Seoul, 05505, South Korea

Samsung Medical Center ( Site 3400)

Seoul, 06351, South Korea

HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 2509)

Barcelona, Catalonia 08036, Spain

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2508)

L'Hospitalet de Llobregat, Catalonia 08908, Spain

Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 2507)

Girona, Gerona 17007, Spain

Clinica Universidad de Navarra ( Site 2510)

Madrid, Madrid, Comunidad de 28027, Spain

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2502)

Madrid, Madrid, Comunidad de 28034, Spain

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 2506)

Madrid, Madrid, Comunidad de 28041, Spain

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2503)

Valencia, Valenciana, Comunitat 46009, Spain

HOSPITAL CLINICO DE VALENCIA ( Site 2505)

Valencia, Valenciana, Comunitat 46010, Spain

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2500)

Barcelona, 08035, Spain

Hospital Universitario Reina Sofia-Oncologia Medica ( Site 2501)

Córdoba, 14004, Spain

Hospital Universitario La Paz-Oncología Médica ( Site 2504)

Madrid, 28046, Spain

Skånes Universitetssjukhus Lund-Department of Hematology ( Site 2602)

Lund, Skåne County 221 85, Sweden

Karolinska Universitetssjukhuset Solna ( Site 2601)

Stockholm, Stockholm County 171 64, Sweden

Akademiska sjukhuset ( Site 2603)

Uppsala, Uppsala County 751 85, Sweden

Universitetssjukhuset i Linköping ( Site 2600)

Linköping, Östergötland County 581 85, Sweden

University Hospital Basel-Gynecology & Gynecologic Oncology ( Site 2701)

Basel, Canton of Basel-City 4031, Switzerland

Inselspital Bern-Oncology ( Site 2700)

Bern, 3010, Switzerland

ROYAL MARSDEN HOSPITAL (CHELSEA)-Gynaecology Research Centre ( Site 2807)

London, England SW10 9NH, United Kingdom

Royal Marsden Hospital (Sutton)-Gynaecology Unit ( Site 2801)

Sutton, England SM2 5PT, United Kingdom

Gartnavel General Hospital-Clinical Trials Unit ( Site 2800)

Glasgow, Glasgow City G12 0YN, United Kingdom

University College London Hospital ( Site 2805)

London, London, City of NW1 2PG, United Kingdom

St James's University Hospital ( Site 2804)

Leeds, LS9 7TF, United Kingdom

The Christie NHS Foundation Trust-Research and Development ( Site 2802)

Manchester, m20 4bx, United Kingdom