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| Name | Class |
|---|---|
| Shulan (Hangzhou) Hospital | OTHER |
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The "no-touch" technique has been one of the most important principles of oncological surgery and aimed to prevent seeding and tumor cell dissemination. Previous studies in hepatectomy have shown that no-touch technique surgery can reduce HCC recurrence and improve the survival of patients. However, there is no consensus on whether the no-touch technique in LT for HCC improves the outcomes. This study aims to prospectively include liver transplant patients from multiple transplant centers, collecting their pre-transplant clinical information, post-transplant pathological records and exploring and clarify the correlation between "no-touch" technique and the prognosis of LT patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HCC patients fulfill Hangzhou criteria and receive LT with "No-touch" technique |
| ||
| HCC patients exceed Hangzhou criteria and receive LT with "No-touch" technique |
| ||
| HCC patients fulfill Hangzhou criteria and receive LT without "No-touch" technique | |||
| HCC patients exceed Hangzhou criteria and receive LT without"No-touch" technique |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liver transplantation with "No-touch" technique | Procedure | The core principle of "no-touch" tumor surgery revolves around avoiding direct contact with the tumor or surrounding tissues as much as possible to minimize the release of cancer cells into the bloodstream or nearby tissues. |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence free surviavl rate | 2024.4.1-2028.4.1 | |
| Overall survival rate | 2024.4.1-2028.4.1 | |
| Tumor recurrence rate | 2024.4.1-2028.4.1 |
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Inclusion Criteria:
Exclusion Criteria:
(1) patients who received split LT or simultaneous transplantation, (2) patients who received re-transplantation, (3) patients with macroscopic portal vein tumor thrombosis or other macrovascular invasion, (4) patients with incomplete follow-up or incomplete important parameters records.
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HCC patients who undergoing deceased donor liver transplantation for the first time.
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| ID | Term |
|---|---|
| D016031 | Liver Transplantation |
| ID | Term |
|---|---|
| D016378 | Tissue Transplantation |
| D064987 | Cell- and Tissue-Based Therapy |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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|
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |
| D013505 |
| Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D016377 | Organ Transplantation |
| D014180 | Transplantation |