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To assess the efficacy of SOD like Super Drink on anti-oxidant capacity, immuno regulation and skin for human
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo drink | Placebo Comparator |
| |
| SOD like Super Drink | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SOD like Super Drink | Dietary Supplement | consume 1 bottle per day |
|
| Measure | Description | Time Frame |
|---|---|---|
| the volume of skin wrinkles | IRV full-face skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units | Volume change from Baseline skin wrinkles at 8 weeks |
| the roughness of skin texture | IRV full-face skin analyzer was utilized to measure skin texture. Units: arbitrary units | Rating skin roughness from Baseline skin texture at 8 weeks |
| the change of skin elasticity | Cutometer® was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 8 weeks |
| the change of Total Anti-oxidative Capacity (TAC) of blood | venous blood was sampled to measure TAC | Change from Baseline TAC at 8 weeks |
| the change of Superoxide Dismutase (SOD) of blood | venous blood was sampled to measure SOD | Change from Baseline SOD at 8 weeks |
| the change of Glutathione S-transferase (GST) of blood | venous blood was sampled to measure GST | Change from Baseline GST at 8 weeks |
| the change of Glutathione (GSH) of blood | venous blood was sampled to measure GSH | Change from Baseline GSH at 8 weeks |
| the change of Malondialdehyde (MDA) of blood |
| Measure | Description | Time Frame |
|---|---|---|
| the change of skin surface hydration | Corneometer® CM 825 was utilized to measure skin surface hydration. Units: arbitrary units | Change from Baseline skin surface hydration at 8 week |
| the change of skin Transepidermal Water Loss (TEWL) |
| Measure | Description | Time Frame |
|---|---|---|
| The change of liver function biomarkers (AST, ALT) of blood | Venous blood was sampled to measure liver function biomarkers | Change from Baseline liver function biomarkers at 8 weeks |
| The change of renal function biomarkers (creatinine, BUN) of blood |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hsiu-Mei Chiang | China Medical University of department of cosmeceutics | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China Medical University of department of cosmeceutics | Taichung | 406040 | Taiwan |
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| placebo drink | Dietary Supplement | consume 1 bottle per day |
|
venous blood was sampled to measure MDA |
| Change from Baseline MDA at 8 weeks |
| the change of immune-related cytokines of blood | venous blood was sampled to measure immune-related cytokines | Change from Baseline immune-related cytokines at 8 weeks |
Tewameter® TM 300 was utilized to measure TEWL. Units: arbitrary units
| Change from Baseline TEWL at 8 week |
| the change of Skin Melanin Index | Mexameter® MX 18was utilized to measure Melanin Index. Units: arbitrary units | Change from Baseline skin Melanin Index at 8 week |
| the change of Skin Erythema Index | Mexameter® MX 18was utilized to measure skin Erythema Index. Units: arbitrary units | Change from Baseline skin Erythema Index at 8 week |
Venous blood was sampled to measure renal function biomarkers
| Change from Baseline renal function biomarkers at 8 weeks |
| The change of self-assessment skin condition and immuno condition | A self-assessment questionnaire was collected to evaluate skin condition and immunol condition，As for the evalutation of skin condition ,the higher score the better；As for evaluation of immunol condition , the higher score the worse | Change from Baseline skin condition and immunol condition at 8 weeks |