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The study investigates whether patients with mild SARS-CoV-2 infection, who stayed at home during their infection and weren't hospitalized, have any persisting sequelae in pulmonary function.
Therefore, 110 patients, aged 6-60 years, were recruited by telephone 4-12 weeks after laboratory-confirmed positive PCR and invited for a lung function testing. Every patient with abnormalities in pulmonary function was invited to a follow-up 3 months after the first appointment to assess changes in lung function values.
Patients with a pre-existing lung disease and smokers within the last five years were excluded beforehand.
Additionally to lung function testing we did a throat swab at each appointment to analyse via Multiplex PCR whether the patients had any other respiratory infection at the time of the pulmonary function testing.
110 patients, 90 adults and 20 children, were recruited. The lung function included LCI, FEV1, FVC and DLCO (Hb corrected). Additionally we did a throat swab at each appointment to analyse via Multiplex PCR whether the patients had any other respiratory infection at the time of the test.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lung function testing | Diagnostic Test | lung function testing including LCI, FEV1, FVC, DLCO |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary function | Pulmonary function after SARS-CoV-2 Infection | 4.3 - 11.3 weeks after positive PCR for SARS-CoV-2 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in pulmonary function | Changes in pulmonary function towards the follow-up | 11.0 - 16.7 weeks after the first lung function testing |
| Sociodemographic factors | Relation of pulmonary function to sociodemographic factors |
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Inclusion Criteria:
Exclusion Criteria:
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SARS-Covid -2 Infection 1 months before investigation
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| Name | Affiliation | Role |
|---|---|---|
| Manfred Ballmann, Prof. Dr. | UMR Kinder- und Jugendklinik | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kinder- und Jugendklinik Universitätsmedizin Rostock | Rostock | 18057 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41199209 | Derived | Gorges AR, Warnke P, Lobermann M, Zapf A, Weitzel J, Steinbach ML, Zufle-Lemke N, Fischer DC, Ballmann M. Pulmonary function in non-hospitalized adults and children after mild COVID-19: a single-centre prospective cohort study. BMC Pulm Med. 2025 Nov 6;25(1):511. doi: 10.1186/s12890-025-04007-y. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| 9 months |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |