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The objective of this study is to assess the long-term outcomes after hospital admission with Covid-19 with respect to pulmonary function, physical capacity, imaging, quality of life and socioeconomic outcomes.
Patients will be invited to follow-up visits 3 and 12 months after hospitalization with COVID19.
Inclusion will take place during 2020. We expect to enroll 180 non-ICU patients and 36 ICU patients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Imaging of the lungs | Diagnostic Test | After hospital admissions with COVID19 patients will come for two clinical visits to complete a number of questionnaires, pulmonary function testing, six-minute walk test, blood sampling and imaging of the lungs. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Imaging of the lungs | Expert evaluation | 3 months after discharge |
| Imaging of the lungs | Expert evaluation | 12 months after discharge |
| Pulmonary function tests | Liter | 3 months after discharge |
| Pulmonary function tests | Liter | 12 months after discharge |
| Six-minute walk test | Walking distance (meters) and change in oxygen saturation. | Performed 3 months after discharge |
| Six-minute walk test | Walking distance (meters) and change in oxygen saturation. | Performed 12 months after discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Short Form-36 (SF-36) questionnaire | 0-100 scale. The lower the score, the more disability. | 3 months after discharge |
| Short Form-36 (SF-36) questionnaire | 0-100 scale. The lower the score, the more disability. |
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Inclusion Criteria:
Exclusion Criteria:
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All patients hospitalized due to infection with Covid-19 and submitted from any of the five hospitals in the Central Denmark Region will be invited to participate.
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| Name | Affiliation | Role |
|---|---|---|
| Elisabeth Bendstrup, MD, PhD | Aarhus University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus University Hospital | Aarhus | Denmark | ||||
| Regional Hospital, Holstebro |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D012129 | Respiratory Function Tests |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Whole blood
| 12 months after discharge |
| Fatigue Assessment Score | 10-50 score. The higher the score, the more fatigue | 3 months after discharge |
| Fatigue Assessment Score | 10-50 score. The higher the score, the more fatigue | 12 months after discharge |
| Cognitive sore (MOCA) | 0-30. The lower the score, the more cognitive impairment | 3 months after discharge |
| Cognitive sore (MOCA) | 0-30. The lower the score, the more cognitive impairment | 12 months after discharge |
| Hospital anxiety and Depression score (HADS) | 0-21. The higher the score, the more risk of anxiety or depression. | 3 months after discharge |
| Hospital anxiety and Depression score (HADS) | 0-21. The higher the score, the more risk of anxiety or depression. | 12 months after discharge |
| Comorbidities | Any pre-COVID-19 comorbidity and treatment with immmunosuppressants will be registered. | 12 months after discharge |
| Blood sample at routine follow up. | Change in outcomes between discharge and follow-up visits will be evaluated | 3 months after discharge |
| Blood sample at routine follow up. | Change in outcomes between discharge and follow-up visits will be evaluated | 12 months after discharge |
| Biobanking of blood | Knowledge regarding COVID19 is drastically evolving. Biobanking makes it possible to investigate blood samples in the future corresponding to ongoing evidence. | 3 months after discharge |
| Biobanking of blood | Knowledge regarding COVID19 is drastically evolving. Biobanking makes it possible to investigate blood samples in the future corresponding to ongoing evidence. | 12 months after discharge |
| Holstebro |
| Denmark |
| Regional Hospital, Horsens | Horsens | Denmark |
| Regional Hospital, Randers | Randers | Denmark |
| Regional Hospital, Silkeborg | Silkeborg | Denmark |
| Regional Hospital, Viborg | Viborg | Denmark |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D003948 | Diagnostic Techniques, Respiratory System |