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The current state of knowledge shows the presence of respiratory sequelae after acute infection with COVID-19 and the importance of these long-term respiratory dysfunctions have to be determined.
Aim of our study is describe diaphragmatic amplitude using diaphragm ultrasonography in patients recovering from SARS-CoV-2 pneumonia at 3 and 6 months after the acute episode.
patients with confirmed COVID-19 who had been discharged from CHRU Hospital in Limoges (France) will be included to follow the impact of severe acute respiratory syndrom coronavirus 2 on pulmonary function, diaphragm function and exercice capacity. Surviving patients will be evaluated at 3 and 6 months after hospital discharge. The assesment will include diaphragm ultrasonography, spirometry (FEV1,FVC), carbon monoxide transfert (TLCO adjusted for haemoglobin), inspiratory an expiratory respiratory muscle strength (Pimax and Pemax) and 6 minutes walk distance (6MWD).The main outcome will be diaphragm excursion assessed by ultrasound.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort | Other | All patients with confirmed COVID-19 who had been discharged from CHRU Hospital in Limoges (France) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| diaphragm ultrasonography | Diagnostic Test | For all patients with confirmed COVID-19 who had been discharged from CHRU Hospital in Limoges (France) : diaphragm ultrasonography at 3 (M0) and 6 months (M3) after the end of his hospitalisation |
| Measure | Description | Time Frame |
|---|---|---|
| The change diaphragmatic amplitude using diaphragm ultrasonography in patients recovering from SARS-CoV-2 pneumonia. | Diaphragmatic amplitude assessed by ultrasound at M0 and M3. | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| Measure | Description | Time Frame |
|---|---|---|
| the correlation between the values of diaphragmatic travel and Pi max and Pe max at M0 and M3. | Diaphragmatic amplitude, PI max and PE max | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| the difference in diaphragmatic amplitude between M0 and M3. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| VINCENT François, Pr | CHU Limoges | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Dupuytren | Limoges | 87042 | France | |||
| chu Limoges |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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Diaphragmatic amplitude at M0 and M3 |
| at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| the difference in FEV1 between M0 and M3. | FEV1 at M0 and M3. | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| the difference in FVC between M0 and M3. | FVC at M0 and M3. | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| the difference in DLCO between M0 and M3. | DLCO at M0 and M3. | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| the difference in Pi max and Pe max between M0 and M3. | PI max and PE max at M0 and M3 | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| dyspnoea between M0 and M3. | mMRC dyspnoea scale at M0 and M3. | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| the functional capacity between M0 and M3. | 6-minutes walk test distance at M0 and M3. | at 3 (M0) and 6 months (M3) after the end of his hospitalisation at the CHU of Limoges |
| Limoges |
| 87042 |
| France |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |