Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Research Foundation Flanders | OTHER |
Not provided
Not provided
Not provided
Not provided
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1: Placebo | Placebo Comparator | Lactose |
|
| H1 blockade: Telfast (180mg Fexofenadine) | Experimental | H1: Telfast (180mg Fexofenadine) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Drug | Oral placebo |
| |
| H1 blockade: Telfast: 180mg Fexofenadine |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle volume | Change in muscle volume | Before and after the 10 weeks of resistance training |
| Maximal dynamic strength of leg press, bench press, bicep curl and leg curl | Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl | Before and after the 10 weeks of resistance training |
| Muscle fiber hypertrophy in muscle biopsies | Change in muscle fiber hypertrophy in muscle biopsies | Before and after the 10 weeks of resistance training |
| Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) | Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) | Before and after the 10 weeks of resistance training |
| Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) | Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) | Before and after the 10 weeks of resistance training |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure (systolic and diastolic) | Chance in Blood pressure (systolic and diastolic) | Before and after the 10 weeks of resistance training |
| Resting heart rate | Chance in Resting heart rate |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wim Derave, Professor | Contact | 92646326 | +32 | wim.derave@ugent.be |
| Name | Affiliation | Role |
|---|---|---|
| Wim Derave, Professor | University Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of movement and sports sciences, Ghent University, Belgium | Recruiting | Ghent | Oost-Vlaanderen | 9000 | Belgium |
Not provided
| ID | Term |
|---|---|
| C093230 | fexofenadine |
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
Not provided
Not provided
Parallel groups
Not provided
Not provided
Not provided
| Drug |
H1 blockade: oral blockade with 180mg Fexofenadine |
|
| Resistance training | Behavioral | Resistance training: lower body exercise |
|
| Before and after the 10 weeks of resistance training |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |