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| Name | Class |
|---|---|
| Research Foundation Flanders | OTHER |
| University of Copenhagen | OTHER |
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Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | 6 weeks high-intensity interval training + placebo intake |
|
| Blockade | Experimental | 6 weeks high-intensity interval training + histamine H1/H2 receptor blockade |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactose | Other | Placebo: Lactose capsules |
| |
| Fexofenadine Hydrochloride |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardiorespiratory fitness | Change in maximal oxygen uptake during incremental cycling test on cycle ergometer during the 6 week training period | Before, after 3 weeks and after 6 weeks of exercise training |
| Change in peak aerobic power output | Change in peak power output during incremental cycling test on cycle ergometer during the 6 week training period | Before, after 3 weeks and after 6 weeks of exercise training |
| Change in whole-body insulin sensitivity | Change from baseline in Matsuda index for whole-body insulin sensitivity derived from Oral Glucose Tolerance Test after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in microvascular function | Change from baseline in microvascular function (Single Passive Leg Movement technique) after the 6 week training period | Before and after 6 weeks of exercise training |
| Measure | Description | Time Frame |
|---|---|---|
| Change in skeletal muscle capillarization | Change from baseline in skeletal muscle capillarization (immunohistochemistry) after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in skeletal muscle enzyme activity |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Movement and Sports Sciences, Ghent University | Ghent | Oost-Vlaanderen | 9000 | Belgium |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D007785 | Lactose |
| C093230 | fexofenadine |
| D015738 | Famotidine |
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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Placebo + exercise vs histamine blockade + exercise
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Double-blind for researchers and participants
| Drug |
H1 receptor antagonist: 540 mg Fexofenadine Hydrochloride |
|
| Famotidine | Drug | H2 receptor antagonist: 40 mg Famotidine |
|
| High-intensity interval training (HIIT) | Other | 6 weeks HIIT |
|
Change from baseline in enzyme activity assessment of markers of relevance for skeletal muscle function after the 6 week training period
| Before and after 6 weeks of exercise training |
| Change in skeletal muscle protein content | Change from baseline in Western Blot assessment of markers of relevance for skeletal muscle function after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in power output at Gas Exchange Threshold (GET) | Change from baseline in GET during incremental cycling test after the 6 week training period | Before, after 3 weeks and after 6 weeks of exercise training |
| Change in power output at Respiratory Compensation Point (RCP) | Change from baseline in RCP during incremental cycling test after the 6 week training period | Before, after 3 weeks and after 6 weeks of exercise training |
| Change in time to exhaustion performance test | Change in time to exhaustion test (performed after incremental cycling test) during the 6 week training period | Before, after 3 weeks and after 6 weeks of exercise training |
| Change in heart rate during submaximal cycling | Change from baseline in heart rate during submaximal cycling after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in substrate oxidation during submaximal cycling | Change from baseline in substrate oxidation during submaximal cycling test (estimated via gas exchange data) after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in blood lactate accumulation during submaximal cycling | Change from baseline in capillary lactate concentration at end of submaximal cycling test after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in cycling efficiency during submaximal cycling | Change from baseline in cycling efficiency (estimated via gas exchange data) after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in fasted serum insulin concentrations | Change from baseline in fasted blood concentrations of insulin after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in fasted serum glucose concentrations | Change from baseline in fasted blood concentrations of glucose after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in fasted serum cholesterol concentrations | Change from baseline in fasted blood concentrations of cholesterol after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in fasted serum triglyceride concentrations | Change from baseline in fasted blood concentrations of triglyceride after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in resting blood pressure | Change from baseline in resting mean arterial blood pressure after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in resting heart rate | Change from baseline in resting heart rate after the 6 week training period | Before and after 6 weeks of exercise training |
| Change in body weight | Change from baseline in total body weight after the 6 week training period | Before and after 6 weeks of exercise training |
| D000073893 |
| Sugars |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |