Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle

Influence of Endurance Training and Histamine Receptor Antagonists on the Transcriptome Response in Human Muscle

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses a twofold research question: "What is the influence of endurance training (1) and histamine H1 and H2 signaling (2) on the gene expression in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Inclusion Criteria:

• Male and female
• 18-45 years
• not to medium physically active

Exclusion Criteria:

• Smoking
• Chronic disease
• Supplement or medication intake
• Seasonal allergies