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The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:
Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).
Researchers will compare the training effects of two different training on these growth factors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High-intensity resistance training group (HIRT) | Experimental | All subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set. |
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| low-intensity resistance training group (LIRT) | Experimental | All subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intensity resistance training | Other | The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Rata of perceived exertion | The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period. | "0 minutes" "60 minutes" "90 minutes" |
| Blood lactate | serum blood lactate | "0 minutes" "60 minutes" "90 minutes" |
| BDNF | regulators of neurogenesis | "0 minutes" "60 minutes" "90 minutes" |
| IGF-1 | regulators of neurogenesis | "0 minutes" "60 minutes" "90 minutes" |
| VEGF | regulators of neurogenesis | "0 minutes" "60 minutes" "90 minutes" |
| Irisin | regulators of neurogenesis | "0 minutes" "60 minutes" "90 minutes" |
| Hcy | homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction | "0 minutes" "60 minutes" "90 minutes" |
| Measure | Description | Time Frame |
|---|---|---|
| Reactive time | Reaction time is the time it takes for the body to go from receiving a stimulus to responding to an action | "0 minutes" "60 minutes" "90 minutes" |
| Accuracy rate | Accuracy refers to the correct degree of expression or description of a thing, which is used to reflect the correct answer to the thing |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chongwen Zuo, Doctoral | Contact | +86 18810716505 | zuochongwen@cupes.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| chongwen zuo, Doctoral | Air Force Medical Center of Chinese PLA | Principal Investigator |
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The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher. First author should be contacted if someone wants to request the data from this study.
When this study was published.
Shall not be used for secondary analysis or repeated publication
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| Low intensity resistance training | Other | For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes. |
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| "0 minutes" "60 minutes" "90 minutes" |