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The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Subjects randomized to the exercise groups will complete 30 minutes of aerobic exercise 3 times a week for 9 weeks incorporating low (group I) or high (group II) intensity aerobic exercise. The exercise will be conducted as running or indoor cycling (supervised). At baseline and 9-weeks follow-up all subjects will complete two cognitive tests (measures of concentration and sustained attention), a maximal cycling test (direct measures of VO2max), an intelligence quotient test, anthropometric measures, fasting blood samples and blood samples immediately following the cycling test. The blood samples will be analyzed for growth factors including BDNF and metabolic factors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High intensity aerobic exercise | Experimental | 30 minutes of high intensity aerobic exercise 3 times a weeks for 9 weeks - incorporation interval training |
|
| Low intensity aerobic exercise | Experimental | 30 minutes of low intensity aerobic exercise 3 times a weeks for 9 weeks |
|
| Control | No Intervention | No intervention. Participants are told not to make any changes in their everyday life |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intensity aerobic exercise | Behavioral |
| ||
| Low intensity aerobic exercise |
| Measure | Description | Time Frame |
|---|---|---|
| The Flanker Task | 9 weeks | |
| The AX-Continuous Performance test | 9 weeks | |
| Brain-derived neurotrophic factor | 9 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Intelligence quotient | 9 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne K Thorsen, Cand. Scient | University of Southern Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Southern Denmark | Odense | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39054765 | Derived | Gejl AK, Bugge A, Ernst MT, Mortensen EL, Gejl KD, Andersen LB. Effects of 9 Weeks of High- or Moderate-Intensity Training on Cardiorespiratory Fitness, Inhibitory Control, and Plasma Brain-Derived Neurotrophic Factor in Danish Adolescents-A Randomized Controlled Trial. Scand J Med Sci Sports. 2024 Aug;34(8):e14703. doi: 10.1111/sms.14703. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| Behavioral |
|