Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the aging brain. Therefore, 50 to 80 years old healthy subjects take part in a prospective study with regular sports activity during 6 months. Cognitive functions are detected with sensitive neuropsychological outcome measures, further investigations include MRT of the head, lactat- and other physical measures as well as detailed serum profiles. As a hypothesis, enhanced physical activity is suggested to predict better cognitive performance.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aerobic Exercise | Experimental |
| |
| Anaerobic Exercise | Experimental |
| |
| Unchanged condition | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition | 6 months | |
| Change of delayed memory scores in #of words in a Verbal learning task after 6 months of intervention/control condition | 6 months | |
| Change of performance in ms in a reaction time task after 6 months of intervention/control condition | 6 months | |
| Change of relative regional grey matter volumes in % measured by T1-weighted MRI after 6 months of intervention/control condition | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change of physical measurements (ECG)/fitness assessments (lactate) after 6 months of intervention/control condition | 6 months | |
| Change of BDNF blood serum levels in ng/dl after 6 months of intervention/control condition | 6 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Agnes Flooel, MD | University Hospital of Muenster | Principal Investigator |
| Stefan Knecht, MD | University Hospital of Muenster | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Muenster | Münster | North Rhine-Westphalia | 48149 | Germany |
Not provided
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
Not provided
Not provided
| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided