Sodium, Nocturnal Blood Pressure and Nocturnal Pauses in Breathing

Sodium, Nocturnal Blood Pressure and Nocturnal Pauses in Breathing

A reduction of dietary sodium intake reduces blood pressure and risk of cardiovascular disease.

A reduction of dietary sodium intake reduces blood pressure and risk of cardiovascular disease. Patients with hypertension resistant of antihypertensive treatment have a high frequency of non-dipping and obstructive sleep apnoea (OSA). The aim of this project is to analyse the effect of dietary sodium restriction on nocturnal blood pressure and nocturnal pauses in breathing in this patients population.

Inclusion Criteria:

• 24h blood pressure > 130/80 mmHg under antihypertensive treatment with three agent, one of these being diuretic. Blood pressure measurement completed after observed intake of antihypertensive medication.
• unchanged antihypertensive treatment for three months
• estimated glomerular function >45 mL/min/1.73 m2

Exclusion Criteria:

• Heart failure assessed from NYHA classification (grade 3-4)
• Presence of clinically significant peripheral edema
• In treatment for obstructive sleep apnea
• Chronic obstructive pulmonary disease (FEV1 <50%)
• Antihypertensive therapy that can not be taken once daily
• Pregnancy or breastfeeding
• Β-albumin <34 g / l
• U-albumin creatinine ratio> 1000 mg / g
• INR> 1.2 (if marevan treatment: ALAT> 200)
• Gluten allergy (dietary guidelines are not adjusted to this group)