The Significance of Sodium Balance and the Value of Salt-blood Test in Identifying Salt Sensitive Patients

The Significance of Sodium Balance for Blood Pressure in Patients With Essential Hypertension and the Value of Salt-blood Test in Identifying Salt Sensitive Patients With Hypertension

This is a randomized controlled trial with 72 patients with hypertension examining the effects on blood pressure of sodium restriction and whether the blood analysis Salt-blood test is associated to a decrease in blood pressure. Patients will be randomized 2:1 to either sodium restriction or usual diet for 4 weeks. Baseline measures will be done before intervention and outcome measures after the 4 weeks.

Inclusion Criteria:

• BMI ≤ 35 kg/m2
• Essential hypertension
• eGFR > 15 ml/min/1,73m2
• Albumine-to-creatinine-ratio < 500 mg/g
• Safe anticonception if women in childbearing age.
• Able to adhere to dietary regimen

Exclusion Criteria:

• Secondary hypertension
• Clinically significant heart failure (NYHA 3-4)
• Clinically significant liver disease
• Diabetes mellitus (type 1 and 2)
• Active cancer (except skin cancer)
• Renal transplant
• Recent stroke, transcient ischemic attack or myocardial infarction (within 6 months)
• Proliferative glomerulonephritis or ANCA-related disease
• Continuous immunosuppressant treatment
• Pregnancy or lactation
• Alcohol abuse
• If the investigator finds the participant unfit to complete the project