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Co-ingesting protein with carbohydrate is an effective way to improve postprandial glucose handling. The investigators have isolated and identified a bioactive protein extracted from seaweed. The investigators aim to explore how varying doses of seaweed protein influence postprandial glycaemia and insulinaemia in a population with type 2 diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | 0.6g/kg body mass maltodextrin in solution |
|
| Protein | Experimental | 0.6g/kg body mass maltodextrin PLUS 0.15g/kg body mass protein from Biodulse, in solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Seaweed protein | Dietary Supplement | Novel protein extracted from seaweed |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial blood glucose area under the curve (AUC) | Integrated area under curve of blood glucose concentration (measured as mmol/L) over 120 minutes | 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Timecourse of blood glucose concentration | Timecourse of blood glucose concentration (measured as mmol/L) | 0, 15, 30, 45, 60, 90, 120 minutes |
| Postprandial serum insulin area under the curve (AUC) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Brian Carson, PhD | University of Limerick | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Limerick | Limerick | V94 T9PX | Ireland |
No individual data will be shared with researchers outside of those named on the institutional ethics application form.
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C008315 | maltodextrin |
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A two arm, acute, randomised, double blind, placebo controlled, crossover design feeding study will be used to establish the impact of co-ingestion of BioDulse (a protein hydrolysate from Irish seaweed) with maltodextrin on postprandial blood glucose and insulin concentrations.
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| Maltodextrin |
| Dietary Supplement |
maltodextrin solution |
|
Integrated area under curve of blood glucose concentration (measured as mU/L) over 120 minutes
| 120 minutes |
| Postprandial serum insulin concentration | Timecourse of serum insulin concentration (measured as mU/L) | 0, 15, 30, 45, 60, 90, 120 minutes |
| D004700 | Endocrine System Diseases |