Efficacy of a Brown Seaweed Powder for Glycemic Control

Efficacy of a Brown Seaweed Powder for Glycemic Control

The objectives of this trial are to confirm efficacy in human of a brown seaweed powder and explore dose-response relationship by comparing two different doses.

The primary endpoint is incremental area under the curve (iAUC, mmol*min/L) for blood glucose.

Inclusion Criteria:

• Males and females aged between 18-45 y
• Normoglycemic (fasting blood glucose <5.6 mmol/L)
• Body mass index (BMI) 18.5-29.9 kg/m2
• Able to consume bread products

Exclusion Criteria

• Fasting blood glucose > 5.6 mmol/L
• Systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg
• Previous history of cardiovascular disease, diabetes, liver or kidney disease, inflammatory bowel disease, celiac disease, short bowel syndrome, any malabsorptive syndrome, pancreatitis, gallbladder or biliary disease
• Presence of a gastrointestinal disorder within the past year
• Presence of major gastrointestinal surgeries
• Thyroid problems
• Smokers
• Consuming prescription or non-prescription drug, herbal or nutritional supplements known to affect blood glucose or that could affect the outcome of the study as per investigator's judgement
• Women that are currently pregnant or lactating, or not using an appropriate contraception method
• Excessive alcohol intake (more than 2 drinks per day or more than 9 drinks per week)
• Allergic to shellfish (crab) or molluscs
• Weight gain or loss of at least 10lbs in previous three months