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| ID | Type | Description | Link |
|---|---|---|---|
| R21DC018906 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
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Researchers will investigate the correlation between a) self-reported dietary intake of foods and beverages, b) intensity of sucrose stimuli, and c) liking rating of sweet stimuli, with the relative expression of the taste receptor genes from human fungiform papillae (TAS1R2 and TAS1R3).
* This research will provide new information on how sweet taste perception is regulated.
Participants will sample solutions prepared with sweet ingredients, provide salivary DNA, and collect fungiform papillae. This will allow researchers and investigators to compare the relationship between the sweetness of stimuli, genetic differences in sweet taste receptors, and expression levels of sweet taste receptor genes.
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| Measure | Description | Time Frame |
|---|---|---|
| Gene expression and sweet taste perception | The relative level of gene expression of sweet taste receptors (TAS1R2 and TAS1R3) and relationship with sweet taste perception (gLMS ratings of sampled sucrose) | Day 1 (single time-point) |
| Gene expression and sweet taste liking | The relative level of gene expression of sweet taste receptors (TAS1R2 and TAS1R3) and relationship with sweet taste perception (hedonic ratings of sampled sucrose) | Day 1 (single time-point) |
| Gene expression and dietary intake | The relative gene level expression of sweet taste receptors and relationship with self-reported dietary intake of sweet foods and beverages | Day 1 (single time-point) |
| Gene expression and sweet liker status | The relative gene level expression of sweet taste receptors and relationship with the self-reported liking of a variety of sweet foods and beverages | Day 1 (single time-point) |
| Measure | Description | Time Frame |
|---|---|---|
| Genetics and sweet taste perception | Genetic variability in sweet taste receptor genes and the relationship with perception of sweet stimuli (gLMS intensity ratings) | Day 1 (single time-point) |
| Genetics and sweet taste liking |
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Inclusion Criteria:
Exclusion Criteria:
-
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Healthy adults, over the age of 18, able to provide consent in English, able to complete survey on an electronic device
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Massachusetts | Amherst | Massachusetts | 01003 | United States |
Data will be shared at the request, after signing release form. No PHI will be included. All data will be de-identified. Data and meta-data will be shared, along with code books.
Data will be available following publication of results.
Individuals can access the following signing form from IRB.
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 12, 2026 | |
| Reset | Jun 8, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 12, 2026 | Jun 8, 2026 |
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saliva, tissue
Genetic variability in sweet taste receptor genes and the relationship with hedonic ratings of sweet stimuli (hedonic ratings)
| Day 1 (single time-point) |
| Genetics and sweet liker status | Genetic variability in sweet taste receptor genes and the relationship with the self-reported liking of sweet-tasting foods and beverages | Day 1 (single time-point) |