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| Name | Class |
|---|---|
| PepsiCo Global R&D | INDUSTRY |
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The purpose of the study is to determine how reducing the amount of simple sugars in the diet affects sweet taste perception. Healthy adult subjects will be assigned to either follow their usual diet, or to replace sugar calories with fats or starch.
The investigators hypothesize that eating less sugar will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No change in dietary sugar levels | Sham Comparator | Group met with a dietician as often as the control group to discuss diet, but the dietician gave them advice geared toward no change in dietary sugar levels |
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| Low sugar group | Experimental | Subjects met with a dietician who discussed diet records. After the first month (baseline, regular diet), the dietician made suggestions geared toward reducing calories from simple sugars by 40%. This will be achieved by replacing sugar calories with complex carbohydrates and fats, while maintaining energy balance (same number of calories as the baseline month). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low sugar diet | Other | All subjects followed their usual diet during month 1. For months 2-4: sham diet intervention for the control group, 40% reduction in sugar calories for the experimental group. All subjects were allowed to chose any diet they wished during month 5. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Sweet Taste Intensity over Five Months | Subjects rated the sweetness of pudding and beverage samples that varied in sucrose concentration during each study month to determine how perception changes over time with diet manipulations | Monthly (for five months) |
| Change in Pleasantness Over Five Months | Subjects rated hedonic value (degree to which the sample was pleasant) for model pudding and beverages that differed in concentration of sucrose once each month over five months to determine how perception changed over time with the diet manipulation | Monthly (five month participation duration total) |
| Measure | Description | Time Frame |
|---|---|---|
| Sucrose detection thresholds | Test of the minimum concentration of sucrose solution that subjects can discriminate from water. Forced-choice, ascending concentration method. | Every month (for five months) |
| Body mass index |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Paul M Wise, PhD | Monell Chemical Senses Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Monell Chemical Senses Center | Philadelphia | Pennsylvania | 19014 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26607941 | Derived | Wise PM, Nattress L, Flammer LJ, Beauchamp GK. Reduced dietary intake of simple sugars alters perceived sweet taste intensity but not perceived pleasantness. Am J Clin Nutr. 2016 Jan;103(1):50-60. doi: 10.3945/ajcn.115.112300. Epub 2015 Nov 25. |
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| Sham diet manipulation | Other | Subjects in the control group will meet with a dietician and discuss diet records, but the dietician will not instruct the control subjects to reduce the number of calories from simple sugars in the diet |
|
BMI, calculated based on weight and height. This was measured both to balance treatment groups and to ensure that assigned diets maintained adequate energy balance (no change in BMI over the study was the ideal outcome for all groups)
| Every month (five months total) |
| Diet records | Subject reported in detail the types and quantities of the foods and beverages they ate. | Every month (five month total) |