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| Name | Class |
|---|---|
| INQUIS Clinical Research | INDUSTRY |
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The purpose of this study is to test the hypothesis that the equivalent glycemic load (EGL) value of portions of white bread containing 5 g available carbohydrate measured in this study is accurate and precise to within 1 gram. Additionally, the EGL of 7 low carbohydrate foods will be measured to determine their glycemic impact.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Peanut Butter Cereal | Experimental | Consumption of Peanut Butter Cereal |
|
| Cinnamon Almond Cereal | Experimental | Consumption of Cinnamon Almond Cereal |
|
| Sriracha Crisps | Experimental | Consumption of Sriracha Crisps |
|
| Cheddar Crisps | Experimental | Consumption of Cheddar Crisps |
|
| Almond Blueberry Butter Bar | Experimental | Consumption of Almond Blueberry Butter Bar |
|
| Peanut Butter and Dark Chocolate Bar | Experimental | Consumption of Peanut Butter and Dark Chocolate Bar |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Food | Other | Food |
|
| Measure | Description | Time Frame |
|---|---|---|
| Equivalent glycemic load | Equivalent glycemic load (EGL) for each test food, expressed as [EGL = T/(W/Cwb)] where T is the plasma glucose incremental area under the curve over 120 minutes (iAUC) elicited by one serving of test food, W is the mean iAUC elicited by the mean of two WB20 tests and Cwb is the amount of available carbohydrate in the WB20. | -5 minutes to 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin iAUC over 120 minutes | Postprandial serum insulin incremental area under the curve over 120 minutes for each food in a subset of n=10 individuals. Blood will be collected at -5, 0, 15, 30, 45, 60, 90, and 120 minutes. | -5 minutes to 120 minutes |
| Glucose iAUC over 120 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| INQUIS Clinical Research, Ltd. | Toronto | Ontario | M5C 2N8 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41439105 | Derived | Wolever TM, Miller K, Banh T. Equivalent Glycemic Load and Insulinemic Responses Elicited by Low-Carbohydrate Foods: A Randomized Trial in Healthy Adults. Curr Dev Nutr. 2025 Oct 30;9(12):107594. doi: 10.1016/j.cdnut.2025.107594. eCollection 2025 Dec. |
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De-identified participant data pertaining to glucose and insulin measurements will be shared upon reasonable request.
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De-identified participant data pertaining to glucose and insulin measurements will be available after publication and will be available until 3 years after the publication date.
Please contact the study sponsor to request access to the data.
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| ID | Term |
|---|---|
| D005502 | Food |
| ID | Term |
|---|---|
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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| Almond Dark Chocolate Bar | Experimental | Consumption of Almond Dark Chocolate Bar |
|
| White Bread 5 g available carbohydrate | Experimental | Consumption of white bread containing 5 g available carbohydrate |
|
| White Bread 20 g available carbohydrate | Active Comparator | Consumption of white bread containing 20 g available carbohydrate |
|
Postprandial plasma glucose incremental area under the curve over 120 minutes for each food in n=25 individuals. Blood will be collected at -5, 0, 15, 30, 45, 60, 90, and 120 minutes. |
| -5 minutes to 120 minutes |