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Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental (Beetroot juice NO3) | Experimental | Acute ingestion of beetroot juice rich in NO3 (800mg). |
|
| Placebo (Beetroot juice without NO3) | Placebo Comparator | Acute ingestion of beetroot juice rich depleted in NO3. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beetroot juice rich in nitrate | Dietary Supplement | The participant will intake beetroot juice rich in NO3 (800mg). Two hours after intake the last bottle of juice, the participants will go to the laboratory for the handgrip and cardiovascular tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols. |
| Measure | Description | Time Frame |
|---|---|---|
| 1. Values of systolic and diastolic blood pressure (mmHg) | up to 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Plasmatic concentrations of nitrate and nitrite (mmol/L) | up to 2 years | |
| Values of heart rate variability (ms) | up to 2 years | |
| Macrovascular function (Flow mediated dilatation%) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cicero Jonas Rodrigues Benjamim, PhD Student | University of Sao Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| EEFERP - USP / Laboratório de Fisiologia do ExercÃcio e Metabolismo | Ribeirão Preto | São Paulo | Brazil |
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| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| ID | Term |
|---|---|
| D009566 | Nitrates |
| ID | Term |
|---|---|
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D007287 | Inorganic Chemicals |
| D017942 |
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|
| Beetroot juice depleted in nitrate | Dietary Supplement | The participant will intake beetroot juice depleted in NO3. Two hours after intake the last bottle of juice, the participants will go to the laboratory for the handgrip and cardiovascular tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols. |
|
| up to 2 years |
| Values of heart rate (beats per minute) | up to 2 years |
| Values of hand grip strength (kgF) | up to 2 years |
| Nitric Acid |
| D017672 | Nitrogen Compounds |
| D009930 | Organic Chemicals |