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Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 15 physically inactive hypertensive women will participate a 8-day trial, each with two intervention protocols: 1) placebo and 2) beetroot; in which will ingest beet juice with or without NO3 in its composition with a 8-day washout interval.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental (Beetroot juice NO3) | Active Comparator | 8-day supplementation with beetroot juice rich in NO3 (400mg) during 8 days. |
|
| Placebo (Beetroot juice without NO3) | Placebo Comparator | 8-day supplementation with beetroot juice NO3 depleted during 8 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beetroot juice rich in nitrate | Dietary Supplement | The participant will intake beetroot juice rich in NO3 (400mg) during 8-days. On the eighth day of the intervention, 2 hours after intake the last bottle of juice, the participants will return to the laboratory for the performance tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols. |
| Measure | Description | Time Frame |
|---|---|---|
| Handgrip strength test (kgf) | up to 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Six minute walk test (distance in meters) | up to 2 years | |
| Arm curl test (repetitions) | up to 2 years | |
| Sit-to-stand test (repetitions) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cicero Jonas Rodrigues Benjamim | Recruiting | Ribeirão Preto | São Paulo | 05508-900 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38805867 | Derived | Benjamim CJR, Lopes da Silva LS, da Silva Goncalves L, Tasinafo Junior MF, Spellanzon B, Rebelo MA, Tanus-Santos JE, Bueno Junior CR. The effects of dietary nitrate ingestion on physical performance tests in 50-65 years old postmenopausal women: A pilot randomized, double-blind, placebo-controlled, and crossover study. Clin Nutr. 2024 Jul;43(7):1642-1646. doi: 10.1016/j.clnu.2024.05.031. Epub 2024 May 22. |
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| ID | Term |
|---|---|
| D008595 | Menorrhagia |
| D057185 | Sedentary Behavior |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D014592 | Uterine Hemorrhage |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D009566 | Nitrates |
| ID | Term |
|---|---|
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D007287 | Inorganic Chemicals |
| D017942 |
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|
| Beetroot juice NO3 depleted | Other | The participant will intake beetroot juice depleted in NO3. On the eighth day of the intervention, 2 hours after intake the last bottle of juice, the participants will to the laboratory for the performance tests evaluation. Before crossover protocol a 7-day washout interval will be given for the purification of the compounds provided by the protocols. |
|
| up to 2 years |
| 8-foot up and go test (seconds) | up to 2 years |
| EEFERP - USP / Laboratório de Fisiologia do Exercício e Metabolismo | Recruiting | Ribeirão Preto | São Paulo | Brazil |
|
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008599 | Menstruation Disturbances |
| D001519 | Behavior |
| Nitric Acid |
| D017672 | Nitrogen Compounds |
| D009930 | Organic Chemicals |