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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Polylevolactic Acid Injection | Experimental | Polylevolactic Acid Injection in SD |
|
| Fractional Laser | Active Comparator | 1565nm Non-ablative Fractional Laser treatment in SD |
|
| combination treatment | Active Comparator | Polylevolactic Acid injection combined with 1565nm Non-ablative Fractional Laser treatment in SD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polylevolactic Acid Injection | Device | The patient was placed in a flat recumbent position and subjected to topical anesthesia with lidocaine cream for those who were unable to tolerate pain. According to the location and degree of indentation of the atrophic stria, a conventional disinfection towel is placed and injected into the subcutaneous and deep dermis. Use left thumb and index finger to press or tighten the skin from both sides to the middle. Depending on the location of the SD, determine the injection direction. During linear injection, the injection starts from the distal end of the SD, and then the injection is withdrawn until the SD subsides. Apply uniform force and withdraw the needle at a uniform speed. Stop the injection before the needle is pulled out of the skin, To avoid too shallow an injection. |
| Measure | Description | Time Frame |
|---|---|---|
| The treatment effect is judged by color, area, concavity and convexity, and skin elasticity |
The total score of 6-12 points is basically cured; A total score of 3-5 points is significant; Effective with a total score of 1-2; A total score ≤ 1 is invalid. Total effective rate of treatment=(basically cured+significantly effective+effective)/total number of cases × 100%. Higher scores mean a better outcome. | 4months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lin Gao, PhD | Contact | +8602984775401 | 029 | gaolin@fmmu.edu.cn |
| Chen Yu, PhD | Contact | _8613571991903 | 029 | ycyc-2005@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Gang Wang, Prof | Dermatology Department of Xijing Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dermatology Derpartment of Xijing Hospital | Recruiting | Xi'an | Shaanxi | 710032 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40662320 | Derived | Qu H, Wang L, Xin W, Lu M, Jing H, Wang G, Gao L. Clinical Efficacy Comparisons Between Poly-L-Lactic Acid Injections and Non-Ablative 1565-nm Fractional Laser for Treatment of Striae Distensae-A Randomized Trial. J Cosmet Dermatol. 2025 Jul;24(7):e70338. doi: 10.1111/jocd.70338. |
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|
| 1565nm Non-ablative Fractional Laser | Device | M22-ResurFx laser (Lumenis Medical Company, USA) was used for treatment, with a wavelength of 1565 nm, a selected energy of 45 mJ, and a lattice density of 200 dots/cm2. The end point reaction was erythema and wind masses at the treatment site. |
|
| Polylevolactic Acid Injection combined with 1565nm Non-ablative Fractional Laser | Device | combination of the two treatments described above |
|
| ID | Term |
|---|---|
| D057896 | Striae Distensae |
| ID | Term |
|---|---|
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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