PRP vs PRF in Management of Striae Distensae

Split-Side Comparative Clinical Study of Platelet-Rich Fibrin Versus Platelet-Rich Plasma With or Without Microneedling in Treatment of Striae Distensae

A split-side comparative clinical study evaluating the efficacy and safety of injectable platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP), alone or combined with microneedling, in the treatment of striae distensae. Thirty patients received PRF or PRP on one side and combination therapy with microneedling on the contralateral side over five sessions. Outcomes included striae width, length, severity score, and patient satisfaction

Inclusion Criteria:

• Adults ≥18 years
• Presence of striae distensae (rubrae or alba)
• Willingness to participate and provide informed consent

Exclusion Criteria:

• Keloid or hypertrophic scar tendency
• Bleeding disorders or anticoagulant use
• Pregnancy
• Active skin infections (e.g., herpes, impetigo, tinea)
• History of malignancy or collagen disease
• Use of antineoplastic drugs
• Conditions impairing wound healing
• Unrealistic expectations