Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
A split-side comparative clinical study evaluating the efficacy and safety of injectable platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP), alone or combined with microneedling, in the treatment of striae distensae. Thirty patients received PRF or PRP on one side and combination therapy with microneedling on the contralateral side over five sessions. Outcomes included striae width, length, severity score, and patient satisfaction
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRF | Active Comparator | Intradermal injection of platelet-rich fibrin |
|
| PRF and Microneedling | Active Comparator | Microneedling followed by topical PRF application |
|
| PRP | Active Comparator | Intradermal injection of platelet-rich plasma |
|
| PRP and microneedling | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PRF group | Biological | Autologous platelet-rich fibrin prepared via single-spin centrifugation without anticoagulant and injected intradermally |
|
| Measure | Description | Time Frame |
|---|---|---|
| The Imam, Nelva, Alviera score (INA score) (Change in striae severity) | The INA score ranges from 0 to 54, with higher scores indicating greater striae distensae severity, therefore representing a worse outcome. Severity was categorized as mild for scores <21, moderate for scores 21-40, and severe for scores >40. | baseline to 1 month after last session |
| Change in striae severity (Imam, Nelva, Alviera score (INA score) | The INA score ranges from 0 to 54, with higher scores indicating greater striae distensae severity, therefore representing a worse outcome. Severity was categorized as mild for scores <21, moderate for scores 21-40, and severe for scores >40. | 1 month after last session |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zagazig University Hospitals | Zagazig | Zagazig-- | 44519 | Egypt |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D057896 | Striae Distensae |
| ID | Term |
|---|---|
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D000097244 | Percutaneous Collagen Induction |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D011677 | Punctures |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| PRP injection | Biological | Intradermal injection of platelet-rich plasma |
|
| PRF and microneedling | Device | Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRF. |
|
| PRP and microneedling | Device | Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRP. |
|
| D012046 |
| Rehabilitation |