The aim of this study is to evaluate and compare the efficacy and safety of microneedling and carboxytherapy either with or without platelet-rich plasma in the treatment of striae distensae rubra.

Inclusion Criteria:

• Female patients.
• Age ranging from 18-45 years old.
• Fitzpatrick skin type III-IV.
• Striae distensae rubra on the abdomen (bilateral and more or less symmetrical).

Exclusion Criteria:

• Patients taking immunosuppressants or having any disease affecting wound healing including diabetes.
• Patients receiving systemic glucocorticoids for chronic health conditions.
• Patients with chronic dermatologic diseases such as psoriasis and vitiligo.
• Pregnant and lactating females.
• Patients with a tendency for keloid formation.
• Patients with endocrine disturbance.
• Patients with autoimmune diseases, systemic diseases such as severe anemia, respiratory, cardiac, renal or liver disorder.
• Patients with bleeding and coagulation disorders.
• Patients who received any form of treatment for their SD in the past 6 months.