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The objective of this study is to evaluate the efficacy and safety of a fractional 1,064 nm picosecond laser for the treatment of striae alba.
Striae distensae are atrophic dermal scars that can cause psychosocial distress on affected patients. Despite numerous available therapeutic modalities, no gold standard therapy has been established. Picosecond lasers are a newer advancement in lasers that have primarily used in the treatment of tattoos. A fractional 1064-nm picosecond laser has recently become available for the treatment of pigmentation and skin rejuvenation. The main mechanism of action is tissue ablation via laser induced optical breakdown (LIOB) which occur when pulse intensity is high enough to strip electrons and generating plasma, the plasma absorbs the remaining laser energy forming a cavitation bubble within the dermis which has been demonstrated to improve fine wrinkles and acne scar through the stimulation of collagen formation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fractional Picosecond 1,064 nm laser | Experimental | The subjects with abdominal striae alba were treated with a fractional picosecond 1,064 nm laser |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fractional picosecond 1,064 nm laser | Device | The parameter of laser was 8-mm spot size, 0.6 mJ/cm2, 750 ps, 10 Hz, 2 passes. The treatment was done in every 4 weeks for 4 sessions. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in striae roughness by Antera 3D image | change from baseline in striae roughness score at 6 months | |
| Change in average Melanin index by Antera 3D image | change from baseline in average melanin index at 6 months | |
| Change in melanin variation index by Antera 3D image | change from baseline in melanin variation index at 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Investigator assessment scores | Clinical improvement was evaluated by comparing pre and post photographs by 2 independent investigators. | Baseline, 1, 3 and 6 months after final treatment |
| Patient satisfaction scores |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Woraphong Manuskiatti, M.D. | Contact | +66819150555 | doctorlaser@gmail.com | |
| Arisa Kaewkes, M.D. | Contact | +66895710956 | searisa@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Siriraj hospital, Mahidol University | Recruiting | Bangkok Noi | Bangkok | 10700 | Thailand |
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| ID | Term |
|---|---|
| D057896 | Striae Distensae |
| ID | Term |
|---|---|
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D007834 | Lasers |
| ID | Term |
|---|---|
| D055096 | Optical Devices |
| D004864 | Equipment and Supplies |
| D055618 | Radiation Equipment and Supplies |
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patient satisfaction questionnaire was done by grading on a scale of 0 to 4; 0: no improvement, 1: <25% improvement, 2: 25-50% improvement, 3: 51-75% improvement, 4: > 75% improvement
| Baseline, 1, 3, and 6 months after final treatment |