Midodrine Effect on the Mortality Rates in Septic Shock P... | NCT05778838 | Trialant

Midodrine Effect on the Mortality Rates in Septic Shock P... | NCT05778838 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Control	Placebo Comparator	Will receive IV vasopressor infusion only	Drug: Midodrine Oral Tablet
Midodrine	Active Comparator	Will receive oral midodrine 10 mg/ 8 hours in addition to IV vasopressor infusion till the end of treatment (subject remaining vasopressor-free for 24 consecutive hours).	Drug: Midodrine Oral Tablet

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Midodrine Oral Tablet	Drug	Patients will receive standard treatment in accordance to surviving sepsis campaign guidelines plus oral midodrine 10 mg/ 8 hours till the end of treatment (subject remaining vasopressor-free for 24 consecutive hours) or death.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Mortality rates	The primary outcome is measuring the difference in ICU mortality rates between control and intervention group.	Time Frame: Starting from date of randomization till shock reversal or date of death from any cause, whichever came first,assessed up to 30 days

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
40241385	Derived	El-Nagdy NK, Mansour NO, Diab AAA, Soliman MM. Efficacy of adjuvant use of midodrine in patients with septic shock: An open label randomized controlled trial. Pharmacotherapy. 2025 May;45(5):264-272. doi: 10.1002/phar.70018. Epub 2025 Apr 16.

Condition Browse Module

Intervention Browse Module