Midodrine Effect on the Mortality Rates in Septic Shock Patients

Clinical Study Evaluating the Efficacy and Safety of Adjunctive Use of Midodrine in Septic Shock Patients

Assessing the safety and efficacy of the adjunctive use of midodrine as a vasopressor in septic shock patients by measuring the difference in the mortality rates between control and intervention groups.

Inclusion Criteria:

• Adult aged 18 years or older diagnosed with septic shock.
• Hypotensive and require IV vasopressor for more than 24 hours.

Exclusion Criteria:

• Hypovolemic shock.
• Severe organic heart disease (ejection fraction <30 percent).
• Bradycardia (HR<50 b/m).
• Chronic kidney disease (serum creatinine >2mg/dl).
• Thyrotoxicosis.
• Pheochromocytoma.
• Known allergy to midodrine.
• Unable to administer an oral medication.