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This study aims to evaluate the effectiveness of midodrine as an adjuvant to norepinephrine in weaning critically ill patients from vasopressors
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Weaning critically ill patients from norepinephrine using midodrine as an adjuvant to norepinephrine | Active Comparator | Patients in group I will receive midodrine (10 mg orally every 8 hours) in addition to administered concurrently with ongoing intravenous norepinephrine after being on norepinephrine for more than 24 h. |
|
| Weaning critically ill patients from norepinephrine without use of midodrine as an adjuvant | Active Comparator | Patients in group II with ongoing intravenous norepinephrine only |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Weaning critically ill patients from norepinephrine using midodrine as an adjuvant to norepinephrine | Drug | • Patients in group I will receive midodrine (10 mg orally every 8 hours) in addition to administered concurrently with ongoing intravenous norepinephrine after being on norepinephrine for more than 24 hrs. |
| Measure | Description | Time Frame |
|---|---|---|
| follow up of critically ill patients on vasopressors | time of weaning from intravenous vasopressor (norepinephrine) | 48 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University Hospital | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34801917 | Background | Costa-Pinto R, Yong ZT, Yanase F, Young C, Brown A, Udy A, Young PJ, Eastwood G, Bellomo R. A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study. J Crit Care. 2022 Feb;67:166-171. doi: 10.1016/j.jcrc.2021.11.004. Epub 2021 Nov 18. | |
| 31030630 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 9, 2026 | |
| Reset | Jun 4, 2026 |
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|
| Weaning critically ill patients from norepinephrine without use of midodrine as an adjuvant | Drug | Patients in group II with ongoing intravenous norepinephrine only |
|
| Hammond DA, Smith MN, Peksa GD, Trivedi AP, Balk RA, Menich BE. Midodrine as an Adjuvant to Intravenous Vasopressor Agents in Adults With Resolving Shock: Systematic Review and Meta-Analysis. J Intensive Care Med. 2020 Nov;35(11):1209-1215. doi: 10.1177/0885066619843279. Epub 2019 Apr 28. |
| 36670331 | Background | Hamed M, Elseidy SA, Elkheshen A, Maher J, Elmoghrabi A, Zaghloul A, Panakos A, Panaich S, Saad M, Elbadawi A. The Use of Midodrine as an Adjunctive Therapy to Liberate Patients from Intravenous Vasopressors: A Systematic Review and Meta-analysis of Randomized Controlled Studies. Cardiol Ther. 2023 Mar;12(1):185-195. doi: 10.1007/s40119-023-00301-0. Epub 2023 Jan 21. |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 9, 2026 | Jun 4, 2026 | |||
| Jul 5, 2026 |
| ID | Term |
|---|---|
| D012769 | Shock |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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