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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| Nutrition Exercise and sports Copenhagen University | UNKNOWN |
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The primary aim of this study is to investigate the acute changes in liver fat content in response to a fixed carbohydrate restriction (i.e. intake of 60g/day or 70g/day for women and men, respectively) in individuals with obesity. This will be performed both as 2 days of very low calorie diet (500 and 600 kcal/day for women and men, respectively) and 2 days of eucaloric low carbohydrate diet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Arm | Experimental | 2 days of eucaloric control diet prior to MRS estimating liver fat (control arm) |
|
| Hypocaloric low carbohydrate | Experimental | 2 days of eucaloric control diet + 2 days of hypocaloric (500-600 kcal m/f) low carbohydrate diet prior to liver fat estimated by MRS and metabolic testday. |
|
| Eucaloric low carbohydrate | Experimental | 2 days of eucaloric control diet + 2 days of eucaloric low carbohydrate diet prior to liver fat estimated by MRS and metabolic testday. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary composition of macronutrients and calories | Other | Carbohydrate restriction |
|
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome is the 1H-Magnetic Resonance Spectroscopy (MRS) determined liver TG content. | We will compare MRS of liver TG after each of the two interventions (2 days of VLCD or 2 days of LC) with MRS liver TG obtained after 2 days of eucaloric conventional diet. | After 2 days completion of dietary intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Secondary outcomes are fasting and postprandial plasma glucose, insulin, and plasma TG concentrations after 2 days VLCD or LC compared with 2 days of eucaloric conventional diet. | After 2 days completion of dietary intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Explorative outcomes | Explorative outcomes are the effects of VLCD and LC on subsequent food intake in response to an ad libitum lunch meal. | After 2 days completion of dietary intervention |
Inclusion Criteria:
Exclusion Criteria:
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Crossover Assignment Randomized diet intervention study in a cross over design
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| D050177 | Overweight |
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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