The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content

The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content

The purpose of this study is to investigate dietary compositions effect on liverfat measured by magnetic resonance imaging.

Overweight but otherwise healthy men will be included in the study which is a randomized diet intervention study in a cross over design.

The study involves 2 intervention periods of 5 days each, during which the participant ingests two different types of experimental diet. Participants will in randomized order (determined by block randomization) ingest a diet with low carbohydrate and high fat content, and a diet with high carbohydrate and low fat content.

Inclusion Criteria:

• Healthy men being 18-50 years old.
• Overweight (BMI 25-35)
• Low to moderate physical activity level, defined as ≤ 1 weekly session of aerobic exercise.
• Non-smokers
• No use of medicine

Exclusion Criteria:

• Fasting blood glucose indicating overt diabetes (≥7 mmol/l)
• HbA1C >48 mmol/mol
• Fasting plasma triacylglycerol indicating dyslipidemia (≥2.2 mmol/l)
• FIB-4 score >1.45
• Contraindications for MR-scan: abdominal height exceed limitations of the MR-scanner, pacemaker or other electronic device implanted, implanted metal devices, severe claustrophobia.