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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| Danish Research Centre for Magnetic Resonance | OTHER |
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The purpose of this study is to investigate dietary compositions effect on liverfat measured by magnetic resonance imaging.
Overweight but otherwise healthy men will be included in the study which is a randomized diet intervention study in a cross over design.
The study involves 2 intervention periods of 5 days each, during which the participant ingests two different types of experimental diet. Participants will in randomized order (determined by block randomization) ingest a diet with low carbohydrate and high fat content, and a diet with high carbohydrate and low fat content.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Carb first | Experimental |
| |
| Low Carb first | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Carb Low Fat Diet | Other | The participants will be randomized to a diet of low carb/ high fat og high carb/low fat |
|
| Measure | Description | Time Frame |
|---|---|---|
| Liverfat | The effect of high-carbohydrate/low-fat vs low-carbohydrate/high-fat diet on change in MRS determined liver fat. | (MRS Day -1 (before intervention starts), Day 5 (after diet intervention is completed) |
| Measure | Description | Time Frame |
|---|---|---|
| Glycogen | effect of the low-carbohydrate/high-fat intake and high-carbohydrate/low-fat intake on hepatic glycogen content measured by 7T 13C-MRS | (MRS Day -1 (before intervention starts), Day 5 (after diet intervention is completed) |
| fasting hepatic glucose output |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Amalie London | Hvidovre | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38914224 | Derived | London A, Richter MM, Sjoberg KA, Wewer Albrechtsen NJ, Povazan M, Drici L, Schaufuss A, Madsen L, Oyen J, Madsbad S, Holst JJ, van Hall G, Siebner HR, Richter EA, Kiens B, Lundsgaard A, Bojsen-Moller KN. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutr. 2024 Aug;120(2):283-293. doi: 10.1016/j.ajcnut.2024.06.006. Epub 2024 Jun 22. |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| D050177 | Overweight |
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D044343 | Overnutrition |
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Randomized diet intervention study in a cross over design
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| Low Carb High Fat Diet | Other | The participants will be randomized to a diet of low carb/ high fat og high carb/low fat |
|
measured by Ra of glucose= (infusion rate of 6,6 2H2-glucose)/TTR |
| (Day 0 and Day 6 of the diet intervention) |
| fasting blood triacylglycerol concentration | (Day 0 and Day 6 of the diet intervention) |
| Insulin clearance determined during steady state insulin infusion | (Day 0 and Day 6 of the diet intervention) |
| D009748 |
| Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |