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This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites.
Participants will engage in three distinct eating plans: a standard diet with usual carbohydrate and calorie levels, a low-carb diet with typical calories, and a low-carb diet with reduced calories. Each diet is followed for a single day, with subsequent monitoring to assess how the body processes food and manages hunger after a meal. The goal is to understand the potential metabolic benefits of reducing carbohydrate intake, either alone or in combination with calorie reduction. This research aims to identify simpler dietary strategies that could improve heart health and assist in weight management without the need for severe calorie restriction or fasting, offering valuable insights for enhancing health outcomes in overweight individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal carbohydrate, energy-balanced diet, (nEB) | Active Comparator | provided participants' 100% daily energy needs, following the balanced Eatwell Guide recommendations. |
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| low-carbohydrate, energy-balanced diet, (LCEB) | Active Comparator | diet contained just 50g of carbohydrates but still met 100% of the participants' estimated daily energy needs. |
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| low-carbohydrate, energy-restricted diet, (LC25) | Active Comparator | The diet consisted of only 50g of carbohydrates and provided 25% of the estimated daily energy needs. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nEB Diet, followed for 36 hours | Other | nEB diet first, then LC25 and LCEB in random order with a 5 days washout between each diet |
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| Measure | Description | Time Frame |
|---|---|---|
| Biomarkers in blood Measured | Measured with ELISA assay and clinical analyser (INDIKO) | 8 hours (fasting and post-meal) |
| Resting metabolic rate | Measured with indirect calorimetry (GEM) | 8 hours (fasting and post-meal) |
| Measure | Description | Time Frame |
|---|---|---|
| Perceived Appetite Scores | Measured with a Visual Analog Scale | 8 hours (fasting and post-meal) |
| Food intake | Measured using food diaries |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hayriye Biyikoglu | University of Surrey | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Surrey | Guildford | GU2 7XH | United Kingdom |
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| LC25 Diet, followed for 36 hours | Other | LC25 diet first, then nEB and LCEB in random order with a 5 days washout between each diet |
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| LCEB Diet, followed for 36 hours | Other | LCEB diet first, then LC25 and nEB in random order with a 5 days washout between each diet |
|
| baseline and after each diet arm for 1 day |