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Thoracic surgery is one of the surgeries where postoperative pain is intense. In this study, the investigators aimed to compare the efficacy of two different intrathecal morphine doses administered for postoperative analgesia according to patients' ideal body weight.
Patients who underwent video-assisted thoracic surgery were divided into two groups: 10 mcg/kg and 7 mcg/kg intrathecal morphine for postoperative analgesia. Intraoperative and postoperative hemodynamic variables, postoperative morphine consumption, postoperative pain scores, side effects and additional analgesic requiretment were recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10 mcg/kg intrathecal morphine | Active Comparator | For postoperative analgesia, before surgical incision, 10 mcg/ideal body weight morphine HCl (in 2 ml volume) was administered intrathecally at L4-5 interspace in the lateral decubitis position. |
|
| 7 mcg/kg intrathecal morphine | Active Comparator | For postoperative analgesia, before surgical incision 7 mcg/ideal body weight morphine HCl (in 2 ml volume) was administered intrathecally at L4-5 interspace in the lateral decubitis position. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Morphine | Drug | In the literature, intrathecal morphine doses were applied according to the patients' actual body weight and there is no study comparing intrathecal morphine dose in thoracic surgery patients. |
| Measure | Description | Time Frame |
|---|---|---|
| pain scores | Postoperative pain scores of the patients were recorded via Visual Analog Scale (VAS; 0= no pain, 10= worst pain) | Change from baseline pain scores at 24 hours |
| morphine consumption | At the end of surgery, patients were allowed to use the patient controlled analgesia (PCA) device. The PCA delivered bolus doses of morphine (0.02 mg/kg) every 10 minutes without a backround infusion. Morphine consumption (mg) was evaluated and recorded postoperative 24 hours. | Change from baseline morphine consumption at 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| systolic arterial blood pressure | Intraoperative systolic arterial blood pressure (mmHg) values were recorded during surgery. | change from baseline systolic blood pressure at 150 minutes |
| diastolic arterial blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cukurova University | Adana | 01130 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D009020 | Morphine |
| ID | Term |
|---|---|
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
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Intraoperative diastolic arterial blood pressure (mmHg) values were recorded during surgery.
| change from baseline diastolic blood pressure at 150 minutes |
| mean arterial blood pressure | Intraoperative mean arterial blood pressure (mmHg) values were recorded during surgery. | change from baseline mean arterial blood pressure at 150 minutes |
| heart rate | Intraoperative heart rate (beats/minute) values were recorded during surgery. | change from baseline heart rate at 150 minutes |
| side effects | All of patients were visited in the thoracic surgery ward after surgery and side effects were evaluated and recorded. | postoperative 24 hours |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D006571 |
| Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |