Study to Assess the Effect of ONS Nutridrink® 200 ml on the Recovery of Patients With COVID-19 and Respiratory Support

Prospective Open-label Comparative in Two-group Investigator-initiated Low-interventional Study to Assess the Effect of Oral Nutritional Supplement (ONS) Nutridrink® 200 ml on the Ability of Patients With COVID-19 to Health Recovery

The goal of this low-interventional study was to learn about the effect a nutritional supplement in patients with COVID-19 and respiratory support. The main questions it aimed to answer were:

• if additional nutrition support has an effect on recovery of physical health in patients with COVID-19;
• to examine the effect of additional nutrition support on quality of life of patients with COVID-19;
• to examine the effect of the additional nutrition support on hospitalization period of patients with COVID-19.

Participants were split into two groups. One group had the common hospital diet, another group in addition to the common diet was given with NutriDrink® 200 ml X 2 daily. During the observation period participants were asked to measure hand strength measured by hand grip tester and fill out the quality of life standard questionnaire SF-36. In addition, several routine blood tests were performed.

Inclusion Criteria:

• Confirmed new coronavirus infection COVID-19 (based on laboratory and/or computer tomography data);
• Need in respiratory support (oxygen insufflation, non-invasive lung ventilation, artificial lung ventilation, as well in a prone position);
• Ability to take food spontaneously in the amount of 60% and more of energy and protein needs (possibility of spontaneous food intake will be determined with the three-swallow test; consumed food will be controlled with the "quarter of a plate" method);
• The informed consent is signed by a patient for the study enrollment and processing of personal data.

Exclusion Criteria:

• Diabetes mellitus;
• Renal failure;
• Hepatic failure;
• Systemic disease;
• Active cancer;
• Poor survival prognosis.
• Aggravation of a patient's condition requiring his transfer to enteral feeding and/or parenteral nutrition;
• Occurrence of complications requiring surgical interventions;
• Patient's transfer for treatment to another inpatient unit;
• Complications induced by the product for additional nutrition support (diarrhea, nausea, vomiting);
• Withdrawal of the informed consent for the study enrollment and processing of personal data.