Nitrate-based Nutritional Formula for Oxygen Saturation and Patient-reported Outcomes in Covid-19

Short-term Intervention With Nitrate-based Nutritional Formula on Oxygen Saturation and Patient-reported Outcomes in Covid-19 Patients

A preliminary open-label case report demonstrated the beneficial effects of an innovative nitrate-based nutritional formula on oxygen saturation in patients with COVID-19. Whether these initial findings are relevant in a more robust research design currently remains unknown. Therefore, the main objective of this randomized controlled trial was to analyze the acute effects of nitrate-based nutritional formula on peripheral SpO2, patient-reported outcomes, and safety indices in patients with acute COVID-19 infection.

Inclusion Criteria:

• age 3 18 years
• confirmed SARS-CoV-2 infection
• SpO2 < 95%
• COVID-19 patients in stable condition (i.e., not requiring hospital admission)

Exclusion Criteria:

• regnant or lactating women
• concomitant pulmonary and cardiovascular conditions
• history of dietary supplement use during the past four weeks
• participation in another COVID-19-related study
• unwillingness to give informed consent