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Aim of the study:
To evaluate clinical and radiographic success rates of silver diamine fluoride versus mineral trioxide aggregate as indirect pulp capping agents in deeply carious young first permanent molars.
Indirect pulp treatment has become a common maneuver in vital pulp therapy in recent years and is a procedure performed in teeth with deep carious lesions approximating the pulp but without any signs or symptoms of irreversible pulpal changes.
Silver Diamine Fluoride is used to arrest caries lesions in primary teeth but according to the AAPD,2021 more research is needed on the use of SDF to arrest caries lesions in permanent teeth.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| silver diamine fluoride group | Experimental | partial caries removal will be carried out then Silver Diamine Fluoride will be applied as indirect pulp capping agent and rubbed for 1 minute followed by Glass ionomer filling |
|
| mineral trioxide aggregate group | Active Comparator | partial caries removal will be carried out then mineral trioxide aggregate will be placed as indirect pulp capping agent followed by glass ionomer filling |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Silver diamine fluoride | Drug | First permanent molars in this group will receive 38% silver diamine fluoride as an indirect pulp capping material. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dentin bridge formation | Dentin bridge formation will be measured in millimeters on standardized digital radiographs taken by Digital Radiographic examination | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain | Postoperative pain will be assessed by questioning the patient or the guardian whether there is postoperative pain or not, Binary (yes or no) | 1 week |
| Absence of sinus or fistula |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marwa Ahmed Ahmed Zaghloul | Contact | +201002798304 | marwa_zaghloul@dentistry.cu.edu.eg | |
| Randa Youssef Abd Al Gawad | Contact | randa.youssef@dentistry.cu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Manal Ahmed El Sayed | Professor of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University | Principal Investigator |
| Randa Youssef Abd Al Gawad | Professor of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University |
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| ID | Term |
|---|---|
| C024633 | silver diamine fluoride |
| C086631 | mineral trioxide aggregate |
| D000068437 | Pemetrexed |
| ID | Term |
|---|---|
| D006147 | Guanine |
| D007042 | Hypoxanthines |
| D011688 | Purinones |
| D011687 | Purines |
| D006574 |
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Two blinded (patient, radiographic assessor of results)
|
| Mineral trioxide aggregate | Drug | First permanent molars in this group will receive mineral trioxide aggregate as an indirect pulp capping material. |
|
|
Intraoral Visual examination will be carried out to assess if there is a sinus or fistula, Binary (present/absent)
| 3 months |
| Absence of sinus or fistula | Intraoral Visual examination will be carried out to assess if there is a sinus or fistula, Binary (present/absent) | 6 months |
| radiographic success | Absence of any adverse radiographic findings (Periodontal membrane space widening, bone resorption, pulp stones will be assessed if present or absent by digital radiographic examination, Binary (present or absent) | 6 months |
| Principal Investigator |
| Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D005971 | Glutamates |
| D024342 | Amino Acids, Acidic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000600 | Amino Acids, Dicarboxylic |