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Comparative study between Biodentine and MTA in direct pulp capping of deeply carious teeth.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Biodentine | Experimental | The exposed area of the pulp is going to be covered with Biodentine. |
|
| MTA | Active Comparator | The exposed area of the pulp is going to be covered with MTA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biodentine | Drug | Biodentine is going to be used as the direct pulp capping material |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Success at 3 months following capping | Case is considered successful if clinical and radiographic examinations of tooth are sound 100%. | the success of treatment is assessed at three months following the application of the material |
| Success at 6 months following capping | Case is considered successful if clinical and radiographic examinations of tooth are sound 100%. | the success of treatment is assessed at six months following the application of the material |
| Success at 9 months following capping | Case is considered successful if clinical and radiographic examinations of tooth are sound 100%. | the success of treatment is assessed at 9 months following the application of the material |
| Success at 12 months following capping | Case is considered successful if clinical and radiographic examinations of tooth are sound 100%. | the success of treatment is assessed at 12 months following the application of the material |
| Success at 18 months following capping | Case is considered successful if clinical and radiographic examinations of tooth are sound 100%. | the success of treatment is assessed at 18 months following the application of the material |
| Success at 24 months following capping | Case is considered successful if clinical and radiographic examinations of tooth are sound 100%. | the success of treatment is assessed at 24 months following the application of the material |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mohammad MN Aldakak, DDS MSc | PhD Student in Operative Dentistry | Principal Investigator |
| Souad Abboud, DDS MSc PhD | Associate Professor of Operative Dentistry, University of Damascus Dental School, Damascus, Syria | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Operative Dentistry, University of Damascus Dental School | Damascus | DM20AM18 | Syria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23402511 | Background | Guneser MB, Akbulut MB, Eldeniz AU. Effect of various endodontic irrigants on the push-out bond strength of biodentine and conventional root perforation repair materials. J Endod. 2013 Mar;39(3):380-4. doi: 10.1016/j.joen.2012.11.033. Epub 2013 Jan 16. | |
| 16764130 | Background | Iwamoto CE, Adachi E, Pameijer CH, Barnes D, Romberg EE, Jefferies S. Clinical and histological evaluation of white ProRoot MTA in direct pulp capping. Am J Dent. 2006 Apr;19(2):85-90. |
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| ID | Term |
|---|---|
| C506393 | tricalcium silicate |
| D000068437 | Pemetrexed |
| ID | Term |
|---|---|
| D006147 | Guanine |
| D007042 | Hypoxanthines |
| D011688 | Purinones |
| D011687 | Purines |
| D006574 |
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| MTA |
| Drug |
MTA is going to be used as the direct pulp capping material in the second group |
|
| 22411260 | Background | Koubi G, Colon P, Franquin JC, Hartmann A, Richard G, Faure MO, Lambert G. Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth - a prospective study. Clin Oral Investig. 2013 Jan;17(1):243-9. doi: 10.1007/s00784-012-0701-9. Epub 2012 Mar 14. |
| 18448160 | Background | Laurent P, Camps J, De Meo M, Dejou J, About I. Induction of specific cell responses to a Ca(3)SiO(5)-based posterior restorative material. Dent Mater. 2008 Nov;24(11):1486-94. doi: 10.1016/j.dental.2008.02.020. Epub 2008 Apr 29. |
| 22892739 | Background | Zanini M, Sautier JM, Berdal A, Simon S. Biodentine induces immortalized murine pulp cell differentiation into odontoblast-like cells and stimulates biomineralization. J Endod. 2012 Sep;38(9):1220-6. doi: 10.1016/j.joen.2012.04.018. Epub 2012 Jul 24. |
| Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D005971 | Glutamates |
| D024342 | Amino Acids, Acidic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000600 | Amino Acids, Dicarboxylic |