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The components of metabolic syndrome (MetS), particularly obesity and dyslipidemia, are linked to peripheral neuropathy (PN) among patients with diabetes or even without diabetes. Several studies revealed that complementary and herbal medicine could provide a potential for PN management and MetS components. Thus, designing clinical trials with interventions combinations to achieve a considerable improvement is highly recommended. Hesperidin and diosmin, citrus-derived flavonoids, have been reported to possess anti-hyperlipidemic, anti-inflammatory, analgesic, antioxidant, antidiabetic, and anti-hypertensive effect with high tolerability and safety profile
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hesperidin group | Active Comparator |
| |
| Diosmin | Active Comparator |
| |
| Hesperidin and diosmin | Active Comparator |
| |
| control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dietary supplement flavonoids | Dietary Supplement | patients were allocated to receive either hesperidin, diosmin, or combination of both and the fourth group was assigned as a control group without intervention |
| Measure | Description | Time Frame |
|---|---|---|
| metabolic syndrome components | Waist circumference, (cm) | 12 weeks |
| metabolic syndrome components | FBG, mg/dl | 12 weeks |
| metabolic syndrome components | LDL, mg/dl | 12 weeks |
| metabolic syndrome components | HDL | 12 weeks |
| metabolic syndrome components | TGs, mg/dl | 12 weeks |
| MNSI score for neuropathy | neuropathy improvement if MNSI score decreased | 12 weeks |
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Inclusion Criteria:
Type 2 diabetes adult patients who meet metabolic syndrome criteria and with diabetic neuropathy
Exclusion Criteria:
patients without any parameter of inclusion criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University | Al Fayyum | 13556 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35946912 | Derived | Osama H, Hamed EO, Mahmoud MA, Abdelrahim MEA. The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial. J Diet Suppl. 2023;20(5):749-762. doi: 10.1080/19390211.2022.2107138. Epub 2022 Aug 10. |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D003929 | Diabetic Neuropathies |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| D009750 |
| Nutritional and Metabolic Diseases |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D048909 | Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |