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To study the effects of Hesperidin, flaxseed and both together in patients with metabolic syndrome, 100 patients will be randomly allocated to one of following four groups: control group, hesperidin group (2 capsules Hesperidin), flaxseed group (30 gram flaxseed) or flaxseed-hesperidin group (2 capsules Hesperidin and 30 gram flaxseed) for 12 weeks; both groups will be advised to adherence the investigators' diet and exercise program too. At the first and the end of the intervention, metabolic factors will be assessed and compared between groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hesperidin and flaxseed | Active Comparator | 1000 mg hesperidin as two capsules and 30 grams flaxseed |
|
| control | Placebo Comparator | no supplementation |
|
| flaxseed | Active Comparator | 30 grams flaxseed |
|
| hesperidin | Active Comparator | 1000 mg hesperidin as two capsules |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hesperidin | Dietary Supplement | 1000 mg hesperidin as two capsules |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic syndrome: Number of participants with treated metabolic syndrome | Number of participants with treated metabolic syndrome | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| azita Hekmatdoost, MD.PhD | Contact | +982122357484 | a_hekmat2000@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Nutrition and Food Technology Research Institute | Recruiting | Tehran | Iran (the Islamic Republic Of) | 1981619573 | Iran |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D006569 | Hesperidin |
| D008043 | Linseed Oil |
| ID | Term |
|---|---|
| D044950 | Flavanones |
| D005419 | Flavonoids |
| D002867 | Chromones |
| D001578 | Benzopyrans |
| D011714 |
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| hesperidin and flaxseed |
| Dietary Supplement |
1000 mg hesperidin as two capsules and 30 grams flaxseed |
|
| flaxseed | Dietary Supplement | 30 grams flaxseed |
|
| control | Other | no supplementation |
|
| D009750 |
| Nutritional and Metabolic Diseases |
| Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006027 | Glycosides |
| D002241 | Carbohydrates |
| D005224 | Fats, Unsaturated |
| D005223 | Fats |
| D008055 | Lipids |
| D010938 | Plant Oils |
| D009821 | Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |