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| Name | Class |
|---|---|
| Sun Yat-sen University | OTHER |
| Guangdong Provincial People's Hospital | OTHER |
| Nanfang Hospital, Southern Medical University | OTHER |
| Fujian Cancer Hospital |
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Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for nasopharyngeal carcinoma identification during biopsy is low, thus leading to delayed or missed diagnosis for nasopharyngeal carcinoma upon initial attempt. Here, we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies and guide biopsy under endoscopic examination based on deep learning.
Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for nasopharyngeal carcinoma identification during biopsy is low, thus leading to delayed or missed diagnosis for nasopharyngeal carcinoma upon initial attempt. Here, we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies and guide biopsy under endoscopic examination based on deep learning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sun Yat-Sen University Cancer Center | The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Sun Yat-Sen University Cancer Center. The physicians in Sun Yat-Sen University Cancer Center consider it necessary to perform an endoscopic image-guided biopsy. |
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| Guangdong Provincial People's Hospital | The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Guangdong Provincial People's Hospital. The physicians in Guangdong Provincial People's Hospital consider it necessary to perform an endoscopic image-guided biopsy. |
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| Nanfang Hospital, Southern Medical University | The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Nanfang Hospital. The physicians in Nanfang Hospital consider it necessary to perform an endoscopic image-guided biopsy. |
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| Fujian Provincial Cancer Hospital | The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Fujian Provincial Cancer Hospital. The physicians in Fujian Provincial Cancer Hospital consider it necessary to perform an endoscopic image-guided biopsy. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nasopharyngeal Endoscopy image-guided Biopsy | Diagnostic Test | For each participant presenting with a suspicious nasopharyngeal lesion, the attending physician will assess the lesion and determine the appropriate biopsy approach. The physician may decide on multiple biopsies from the lesion area, including one sample from within the lesion itself, another from 5-8 mm outside the lesion, and a third from 8-10 mm beyond the lesion. Alternatively, a single biopsy may be deemed sufficient based on the clinical judgment. Each of these specimens will undergo pathological examination to confirm whether they are carcinomatous or non-carcinomatous. |
| Measure | Description | Time Frame |
|---|---|---|
| Aera under the receiver operating characteristic curve (AUC) | AUC of an deep learning-based model in discriminating nasopharyngeal carcinoma from bengin lesion. | three months |
| Measure | Description | Time Frame |
|---|---|---|
| Accuray | The agreement between the deep learning-based model and the histopathological diagnosis of the three biopsy specimens (inside the lesion, 5-8 mm outside the lesion, and 8-10 mm outside the lesion). | three months |
| Measure | Description | Time Frame |
|---|---|---|
| Statistical significance | Statistical significance (P value) of DFS (time from diagnosis to disease progression or death from any cause) in nasopharyngeal carcinoma patients between high-risk and low-risk group identified by deep learning-based model. | Three years |
Inclusion Criteria:
Exclusion Criteria:
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The patient was found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy and the clinican considered it necessary to perform an endoscopic image-guided biopsy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Di Dong, Ph.D | Contact | +86 010-82618465 | di.dong@ia.ac.cn | |
| Yali Zang, ph.D | Contact | yali.zang@ia.ac.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fujian Provincial Cancer Hospital | Recruiting | Fuzhou | Fujian | 350014 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33393666 | Background | Zwakenberg MA, Halmos GB, Wedman J, van der Laan BFAM, Plaat BEC. Evaluating Laryngopharyngeal Tumor Extension Using Narrow Band Imaging Versus Conventional White Light Imaging. Laryngoscope. 2021 Jul;131(7):E2222-E2231. doi: 10.1002/lary.29361. Epub 2021 Jan 4. | |
| 30253801 | Result | Li C, Jing B, Ke L, Li B, Xia W, He C, Qian C, Zhao C, Mai H, Chen M, Cao K, Mo H, Guo L, Chen Q, Tang L, Qiu W, Yu Y, Liang H, Huang X, Liu G, Li W, Wang L, Sun R, Zou X, Guo S, Huang P, Luo D, Qiu F, Wu Y, Hua Y, Liu K, Lv S, Miao J, Xiang Y, Sun Y, Guo X, Lv X. Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies. Cancer Commun (Lond). 2018 Sep 25;38(1):59. doi: 10.1186/s40880-018-0325-9. |
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| OTHER_GOV |
| Hainan People's Hospital | OTHER |
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For each participant exhibiting suspicious lesions during a nasopharyngeal endoscopy examination, the attending physician will determine the appropriate biopsy strategy based on the specific conditions of the lesion. The physician may opt for a single biopsy, taking a sample directly from within the lesion, or multiple biopsies, which would include one sample from inside the lesion, another from 5-8 mm outside the lesion, and a third from 8-10 mm outside the lesion. This decision will be grounded in clinical judgment and a comprehensive consideration of optimal diagnostic outcomes and patient safety.
| Hainan Provincial People's Hospital | The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Hainan Provincial People's Hospital. The physicians in Hainan Provincial People's Hospital consider it necessary to perform an endoscopic image-guided biopsy. |
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| Guangdong Provincial People's Hospital | Recruiting | Guangzhou | Guangdong | 510060 | China |
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| Nanfang Hospital, Southern Medical University | Recruiting | Guangzhou | Guangdong | 510060 | China |
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| Sun Yat-Sen University Cancer Center | Recruiting | Guangzhou | Guangdong | 510060 | China |
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| Hainan Provincial People's Hospital | Recruiting | Haikou | Hainan | 570311 | China |
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| ID | Term |
|---|---|
| D000077274 | Nasopharyngeal Carcinoma |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009303 | Nasopharyngeal Neoplasms |
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009302 | Nasopharyngeal Diseases |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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