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This study is a randomized, controlled, double-blinded, and parallel design study. A total 94 patients will be randomized to receive ketorolac or fentanyl based patient-controlled analgesia after microvascular decompression surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NSAID group | Experimental | NSAID based patient-controlled analgesia will connected to intravenous line for pain control. |
|
| Opioid group | Active Comparator | Opioid based patient-controlled analgesia will connected to intravenous line for pain control. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NSAID | Drug | NSAID based patient-controlled analgesia will connected to intravenous line for pain control. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative nausea and vomiting | Incidence | postoperative 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative nausea and vomiting | Severity accessed using numeric rating scale (0=none, 10=worst PONV possible) | Postoperative 30 minutes, 1 hours, 24 hours, 48 hours |
| Postoperative pain | pain intensity will be assessed using numeric rating scale (0=none, 10=worst pain possible) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chang-Hoon Koo | Contact | +821085098841 | vollock9@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Chang-Hoon Koo | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
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| ID | Term |
|---|---|
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009325 | Nausea |
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| ID | Term |
|---|---|
| D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| D000701 | Analgesics, Opioid |
| ID | Term |
|---|---|
| D018712 | Analgesics, Non-Narcotic |
| D000700 | Analgesics |
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
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| Opioid | Drug | Opioid based patient-controlled analgesia will connected to intravenous line for pain control. |
|
| Postoperative 30 minutes, 1 hours, 24 hours, 48 hours |
| Postoperative PCA consumption | Postoperative 30 minutes, 1 hours, 24 hours, 48 hours |
| Rescue antiemetics requirement | Postoperative 30 minutes, 1 hours, 24 hours, 48 hours |
| Rescue analgesic requirement | Postoperative 30 minutes, 1 hours, 24 hours, 48 hours |
| Satisfaction score for postoperative nausea and vomiting | using 11-point scale (0=Worst dissatisfied, 10=Very satisfied) | postoperative 48 hours |
| Satisfaction score for postoperative pain | using 11-point scale (0=Worst dissatisfied, 10=Very satisfied) | postoperative 48 hours |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D014839 | Vomiting |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D000893 | Anti-Inflammatory Agents |
| D045506 | Therapeutic Uses |
| D018501 | Antirheumatic Agents |
| D009294 | Narcotics |
| D002492 | Central Nervous System Depressants |
| D002491 | Central Nervous System Agents |