The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.

Inclusion Criteria:

1. Males and females aged 14-23 years old

2. Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:

   1. Triathlon
   2. Cycling
   3. Distance running (≥ 1500 meters)
   4. Rowing
   5. Swimming

3. Non athletes engaged in < 3 hours per week of physical activity

Exclusion Criteria:

1. Medical history of cardiovascular disease
2. Current smoker of past history of smoking
3. Diabetes mellitus

Athletes aged 14 to 23 years recruited from elite endurance sports programs and organisations including Cycling Vlaanderen, Triatlon Vlaanderen, Belgian Cycling, Cycling Australia, Rowing Australia and Athletics Australia and from sports performance centres including Nottebohm Antwerpen, Bakala Academy Leuven and Adlon Hasselt. Volunteers recruited by means of 'word of mouth' and social media campaigns within elite endurance sporting circles. Non-athletes consist of age and gender matched university and college students recruited from Australian and Belgian universities in addition to social media campaigns.