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Prospective, nonrandomized, single-center, comparative study to define if right ventricular (RV) contractile reserve assessed by exercise CMR helps to improve the differential diagnosis between pathological and physiological remodeling of the RV; ie. arrhythmogenic right ventricular cardiomyopathy (ARVC) and athlete's heart.
Comparison of the RV contractile reserve in 4 groups of patients: Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients; endurance athletes with a dilated RV, endurance athletes with normal RV, untrained subject with normal RV.
Patients will come to the hospital for 3 visits (3 half days):
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ARVC patients | Experimental |
| |
| Endurance athletes with a dilated RV | Active Comparator |
| |
| Endurance athletes with normal RV | Active Comparator |
| |
| Untrained subject with normal RV | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac exercises and tests | Other | Rest ECG, rest echocardiography, cardio-pulmonary exercise test, exercise echocardiography, holter ECG monitor (48 yours), rest CMR, exercise CMR (ergocycle) |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of right ventricular ejection fraction (RVEF) assessed with CMR during exercise | Through study completion, an average of 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of Tricuspid annular plane systolic excursion (TAPSE) during exercise | Through study completion, an average of 1 month | |
| Evolution of S' tricuspid wave during exercise | Through study completion, an average of 1 month |
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Inclusion Criteria:
Men or women aged 18 years and older,
who signed a written free and informed consent:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Frédéric SCHNELL, MD-PhD | Contact | +33 2.99.28.41.33 | Frederic.SCHNELL@chu-rennes.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Rennes | Recruiting | Rennes | 35033 | France |
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| Evolution of RV fractional area during exercise | Through study completion, an average of 1 month |
| Evolution of free wall RV strain during exercise | Through study completion, an average of 1 month |
| ID | Term |
|---|---|
| D019571 | Arrhythmogenic Right Ventricular Dysplasia |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D001519 | Behavior |
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