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The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of liver cirrhosis .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group: | patients with liver cirrhosis |
| |
| Control group | patients without liver cirrhosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SNP analysis of the DNA | Genetic | SNP analysis of the DNA obtained from peripheral blood sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| genotyping for the SNP associated with liver cirrhosis | Genotype frequency of SNP in the study genes of participants and control participants. | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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KAZAKH POPULATION
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| Name | Affiliation | Role |
|---|---|---|
| Bibigul Saparbekovna, PhD | JSC "National Scientific Center of Surgery named after A.N. Syzganova " | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Scientific Center of Surgery named after A.N. Syzganova | Almaty | Kazakhstan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37580657 | Derived | Ilyassova BS, Abzhaparova B, Smailova DS, Bolatov A, Baymakhanov B, Beloussov V, Solomadin M, Shamsivaliyeva K, Alpysbayava G, Issakova G, Granica J, Mukushkina D, Sagatov IY, Kaniyev S. Prevalence and genotypes distribution of virus hepatitis B and hepatitis delta virus in chronic liver diseases in Kazakhstan. BMC Infect Dis. 2023 Aug 14;23(1):533. doi: 10.1186/s12879-023-08524-1. |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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Blood
| D013568 |
| Pathological Conditions, Signs and Symptoms |