The Role of Genetic Factors in the Development of Idiopathic Osteoarthritis of the Knee in the Kazakh Population

Preventive and Personalized Medicine (2021-2023)

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee

Inclusion Criteria:

1. Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years;
2. Representatives of the Kazakh ethnic group up to the 3rd generation;
3. Hereditary history of arthrosis;
4. Persons who are able and willing to provide written informed consent;

Exclusion Criteria:

1. Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age;
2. Representatives of other ethnic groups;
3. Representatives of the Kazakh ethnic group less than 3 generations;
4. No family history of bilateral idiopathic gonarthrosis;
5. Patients with an acute period of the inflammatory process (laboratory and clinical signs);
6. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
7. Pregnant or lactating women;
8. Tuberculosis of any localization in the active phase and in history;
9. Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
10. Severe and decompensated course of endocrine diseases;
11. Autoimmune diseases;
12. Systemic diseases;
13. Oncological diseases;