The Role of Genetic Factors in the Development of Idiopathic Scoliosis in the Kazakh Population

Preventive and Personalized Medicine (2021-2023)

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic scoliosis

Inclusion Criteria:

1. Persons with a doctor-confirmed diagnosis of idiopathic scoliosis;
2. Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs;
3. Hereditary history of scoliosis;
4. Persons who are able and willing to provide written informed consent;

Exclusion Criteria:

1. Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age;
2. Representatives of the Kazakh ethnic group less than 3 generations;
3. No family history of bilateral idiopathic scoliosis;
4. Patients with an acute period of the inflammatory process (laboratory and clinical signs);
5. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
6. Pregnant or lactating women;
7. Tuberculosis of any localization in the active phase and in history;
8. Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
9. Severe and decompensated course of endocrine diseases;
10. Autoimmune diseases;
11. Systemic diseases;
12. Oncological diseases;