Study of the Prognostic Role of Gene Polymorphism in the Development of B-cell Leukemias and Lymphomas in Children of Kazakh Nationality

Preventive and Personalized Medicine (2021-2023)

To search for a genetic marker of B-cell leukemias and lymphomas in children of Kazakh nationality, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with B-cell leukemias and lymphomas in children of Kazakh nationality and normal control will be performed.

Inclusion Criteria:

• ethnicity - Kazakhs in at least three generations
• active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation
• Signed voluntary informed consent of the legal representative to participate in the project

Exclusion Criteria:

• Children suffering from other types of malignant neoplasms
• Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases
• Children of non-Kazakh nationality
• Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy